TFR2 antibody | MyBioSource MBS833691 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TFR2 antibody

catalog :

MBS833691

quantity :

0.1 mL

price :

725 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[1B1]

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

image

image 1 :

Flow Cytometric analysis of HEK293T cells transfected with either recombinant TFR2 protein (red) or empty vector (blue) stained using TFR2 antibody

image 2 :

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant TFR2 protein (Right) or empty vector (Left) detected with TFR2 antibody

image 3 :

Immunofluorescent staining of COS7 cells transiently transfected with recombinant TFR2 protein using TFR2 antibody

product information

catalog number :

MBS833691

products type :

Antibody

products full name :

TFR2 antibody

products short name :

[TFR2]

products name syn :

[Monoclonal TFR2; Anti-TFR2; HFE3; MGC126368; TFRC2; TFR2; TFR 2; TFR-2]

other names :

[transferrin receptor protein 2 isoform 2; Transferrin receptor protein 2; transferrin receptor protein 2; transferrin receptor 2]

products gene name :

[TFR2]

other gene names :

[TFR2; TFR2; HFE3; TFRC2; TfR2]

uniprot entry name :

TFR2_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

[1B1]

host :

Mouse

reactivity :

Human, Monkey, Mouse

sequence length :

630

purity :

TFR2 antibody was purified by affinity chromatography.

form :

Liquid in PBS, pH 7.3 containing 1% BSA, 50% Glycerol and 0.02% sodium azide as a preservative.

concentration :

1.13 mg/mL

storage stability :

Upon receipt at -20°C . Avoid repeat freeze-thaw cycles.

tested application :

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

app notes :

WB: 1:500-1:2000. IF: 1:100. Flow: 1:100

image1 heading :

Flow Cytometry (FC/FACS)

image2 heading :

Western Blot (WB)

image3 heading :

Immunofluorescence (IF)

other info1 :

Biological Significance: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III.

other info2 :

Immunogen: Full length recombinant protein of human TFR2 produced in HEK293T cell

products categories :

Signal Transduction

products description :

Mouse monoclonal TFR2 antibody

ncbi gi num :

332309171

ncbi acc num :

NP_001193784.1

ncbi gb acc num :

NM_001206855.1

uniprot acc num :

Q9UP52

ncbi pathways :

Iron Metabolism In Placenta Pathway (672461)

ncbi summary :

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

uniprot summary :

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: integral to plasma membrane; cytoplasm. Molecular Function: transferrin receptor activity. Biological Process: receptor-mediated endocytosis; cellular iron ion homeostasis; iron ion transport. Disease: Hemochromatosis, Type 3

size1 :

0.1 mL

price1 :

725 USD

more info or order :

MyBioSource product webpage