Complement C1q antibody | MyBioSource MBS833440 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Complement C1q antibody

catalog :

MBS833440

quantity :

1 mg

price :

350 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS833440

products type :

Antibody

products full name :

Complement C1q antibody

products short name :

Complement C1q

products name syn :

Polyclonal Complement C1q; Anti-Complement C1q; Complement Cq -1; Complement Cq 1; C1q; Complement C1q

other names :

complement C1q subcomponent subunit C; Complement C1q subcomponent subunit C; complement C1q subcomponent subunit C; complement component 1, q subcomponent, C chain

other gene names :

C1QC; C1QC; C1QG; C1Q-C; C1QG

uniprot entry name :

C1QC_HUMAN

clonality :

Polyclonal

host :

Goat

sequence length :

245

specificity :

Complement C1q antibody was raised against Human Complement C1q.

purity :

> 95% pure. Affinity purified using solid phase Human Complement C1q

form :

Clear, colorless liquid, 0.2 um filtered, containing 10 mM Sodium Phosphate, 0.15 M Sodium Chloride and 0.05% (w/v) Sodium Azide. Protease/IgG free.

concentration :

>4.5 mg/ml

storage stability :

Store at 2-8 degree C.

tested application :

User optimized

app notes :

The optimal working dilution should be determined by the end user

other info1 :

Source Note: Goat serum was obtained from healthy animals of US origin and under the care of a registered veterinarian. Biological Significance: The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. The sites are on the CH2 domain of IgG and, it is thought, on the CH4 domain of IgM. The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.

other info2 :

Immunogen: Human Complement C1q

products categories :

Immunology; Purified Polyclonal Antibodies

products description :

Affinity purified Goat polyclonal Complement C1q antibody

ncbi gi num :

166235903

ncbi acc num :

NP_001107573.1

ncbi gb acc num :

NM_001114101.1

uniprot acc num :

P02747

ncbi mol weight :

25,774 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

ncbi summary :

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: extracellular space; collagen; extracellular region. Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; negative regulation of granulocyte differentiation; complement activation. Disease: C1q Deficiency

size1 :

1 mg

price1 :

350 USD

more info or order :

MyBioSource product webpage