catalog number :
MBS833424
products full name :
Peroxiredoxin III antibody
products short name :
[Peroxiredoxin III]
products name syn :
[Monoclonal Peroxiredoxin III; Anti-Peroxiredoxin III; PRDX3; peroxiredoxin 3; 5'-methylthioadenosine phosphorylase; anti-oxidant like protein-1; antioxidant protein; anti-oxidant protein 1; antioxidant protein 1; aop-1; AOP1; BOS_23591; D0Tohi1; Ef2l; HBC189; Mer5; mitochondrial thioredoxin dependent peroxide reductase; mitochondrial thioredoxin-dependent peroxide reductase; mitochondrial Trx dependent peroxide reductase; MTAP; MTAPase; MTA phosphorylase; perioredoxin-3; peroxiredoxin-3; peroxiredoxin III; PRO1748; protein MER5 homolog; prx3; PRX-3; prx-III; Prx III; sp22; SP-22; TDXM; thioredoxin-dependent peroxide reductase; mitochondrial]
other names :
[peroxiredoxin III; Thioredoxin-dependent peroxide reductase, mitochondrial; thioredoxin-dependent peroxide reductase, mitochondrial; peroxiredoxin 3; Antioxidant protein 1; AOP-1; PRX III; Perioredoxin-3; Protein MER5]
other gene names :
[Prdx3; Prdx3; Aop1; Ef2l; Mer5; Prx3; SP22; TDXM; D0Tohi1; AW822249; Aop1; Mer5; AOP-1]
uniprot entry name :
PRDX3_MOUSE
reactivity :
Human, Mouse, Rat
purity :
Peroxiredoxin III antibody was purified by ammonium sulfate precipitation
form :
Protein G purified liquid in HEPES with 150 mM NaCI, 0.01% BSA, 0.03% NaN 3 , and 50% Glycerol.
concentration :
1.0 mg/mL
storage stability :
4°C for short term, -20°C for long term. Avoid repeat freeze thaws.
tested application :
Suitable for use in Western Blot (WB), and Immunoprecipitation (IP).
app notes :
Western Blot (WB): 1:2000-1:5000. Immunoprecipitation (IP): 1 ul
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant mouse protein purified from E.coli.
other info2 :
Biological Significance: Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology particularly amino terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms.
products categories :
Signal Transduction
products description :
Mouse monoclonal Peroxiredoxin III antibody
ncbi acc num :
AAF63705.1
ncbi pathways :
Cellular Responses To Stress Pathway (1168727); Detoxification Of Reactive Oxygen Species Pathway (1168733)
uniprot summary :
PRDX3: Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Belongs to the AhpC/TSA family. Protein type: EC 1.11.1.15; Oxidoreductase. Cellular Component: mitochondrion; cytoplasm; early endosome; IkappaB kinase complex; cytosol; myelin sheath. Molecular Function: protein C-terminus binding; antioxidant activity; identical protein binding; peroxidase activity; thioredoxin peroxidase activity; peroxiredoxin activity; caspase inhibitor activity; oxidoreductase activity; kinase binding; protein kinase binding. Biological Process: mitochondrion organization and biogenesis; negative regulation of kinase activity; response to lipopolysaccharide; negative regulation of caspase activity; activation of NF-kappaB transcription factor; peptidyl-cysteine oxidation; response to hydrogen peroxide; regulation of mitochondrial membrane potential; hydrogen peroxide catabolic process; positive regulation of cell proliferation; myeloid cell differentiation; negative regulation of neuron apoptosis; response to oxidative stress; maternal placenta development; negative regulation of apoptosis