catalog number :
MBS833279
products full name :
Prothrombin precursor antibody
products short name :
[Prothrombin precursor]
products name syn :
[Monoclonal Prothrombin precursor; Anti-Prothrombin precursor; F2; coagulation factor II (thrombin); Cf2; Cf-2; coagulation factor 2; coagulation factor 2 (thrombin); coagulation factor II; F2_BB; FII; Prothrombin; prothrombin B-chain; prothrombin precursor; PT; RP23-176N9.4; RPRGL2; serine protease; silk fibroin 2; THPH1; thrombin; thrombin B chain variant 1; vitamin K dependent serine protease]
purity :
Prothrombin precursor antibody was purified by ammonium sulfate precipitation
form :
Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
storage stability :
4 degree C shipping. Upon receipt store at at -20 degree C, avoid freeze/thaw cycles
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: (0.5mg/ml)
image1 heading :
Western Blot (WB)
other info1 :
Biological Significance: Prothrombin precursor is synthesized in liver as a precursor of prothrombin containing a signal sequence and a propeptide domain at the N-terminus. Before its secretion into plasma, this precursor undergoes several posttranslational modifications, including removal of signal sequence and propeptide domains, glycosylation, and gamma-glutamyl-carboxylation reaction. Prothrombin, cleaved by the prothrombinase enzyme complex that consists of serine protease factor Xa, cofactor Va, phospholipids and calcium, is converted to thrombin which converts fibrinogen into fibrin which in turn strengthens a protective clot. Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin (e.g. hypoprothrombinemia) have been described.
other info2 :
Immunogen: Prothrombin precursor antibody was raised in Mouse using a protein purified from Human plasma as the immunogen
products categories :
Cell Biology
products description :
Mouse monoclonal Prothrombin precursor antibody