A1AT antibody | MyBioSource MBS833220 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

A1AT antibody

catalog :

MBS833220

quantity :

10 mL

price :

180 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS833220

products type :

Antibody

products full name :

A1AT antibody

products short name :

A1AT

products name syn :

Polyclonal alpha 1 Antitrypsin; Anti-alpha 1 Antitrypsin; AAT; alpha 1 antitrypsin; A1AT; alpha 1 antiproteinase; alpha 1 protease inhibitor

other names :

alpha-1-antitrypsin; Alpha-1-antitrypsin; alpha-1-antitrypsin; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1

products gene name :

A1AT

other gene names :

SERPINA1; SERPINA1; PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT; AAT; PI; SPAAT

uniprot entry name :

A1AT_HUMAN

clonality :

Polyclonal

host :

Goat

sequence length :

418

specificity :

Human

form :

Supplied as serum, 0.1% NaN3.

storage stability :

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw Cycles

tested application :

User optimized

other info1 :

Biological Significance: Alpha 1-Antitrypsin or alpha1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 1.5 - 3.5 gram/liter (in US the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation.

other info2 :

Immunogen: Alpha-1 antitrypsin antibody was raised in goat using human alpha-1 antitrypsin as the immunogen.

products categories :

Proteases, Inhibitors, & Enzymes

products description :

Goat polyclonal Human alpha 1 Antitrypsin antibody

ncbi gi num :

189163542

ncbi acc num :

NP_001121179.1

ncbi gb acc num :

NM_001127707.1

uniprot acc num :

P01009

ncbi mol weight :

34,755 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); FOXA1 Transcription Factor Network Pathway (137979); Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

ncbi summary :

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Inhibitor; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: Golgi apparatus; extracellular space; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding. Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; response to hypoxia; response to methanol; acute-phase response; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus. Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive

size1 :

10 mL

price1 :

180 USD

more info or order :

MyBioSource product webpage