SLC18A2 antibody | MyBioSource MBS833162 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SLC18A2 antibody

catalog :

MBS833162

quantity :

0.1 mL

price :

760 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[9 E11]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant SLC18A2 protein (Right) or empty vector (Left) detected with SLC18A2 antibody

image 2 :

Immunohistochemical analysis of SLC18A2 protein in paraffin embedded Human pancreas tissue using SLC18A2 antibody

image 3 :

Immunofluorescent staining of COS7 cells transiently transfected with recombinant SLC18A2 protein using SLC18A2 antibody

product information

catalog number :

MBS833162

products type :

Antibody

products full name :

SLC18A2 antibody

products short name :

[SLC18A2]

products name syn :

[Monoclonal SLC18A2; Anti-SLC18A2; Solute Carrier Family 18 Member 2; Vesicular Monoamine 2; MGC120477; MGC120478; MGC26538; SVAT; SVMT; VAT2; VMAT2; SLC18A2; SLCA2 18; SLCA2-18]

other names :

[SLC18A2 protein; Synaptic vesicular amine transporter; synaptic vesicular amine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2]

products gene name :

[SLC18A2]

other gene names :

[SLC18A2; SLC18A2; SVAT; SVMT; VAT2; VMAT2; SVMT; VMAT2; VAT2]

uniprot entry name :

VMAT2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[9 E11]

host :

Mouse

reactivity :

Human

sequence length :

209

purity :

SLC18A2 antibody was purified by affinity chromatography.

form :

Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

FC: 1:100. IF: 1:100. IHC: 1:50. WB: 1:2000

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunofluorescence (IF)

other info1 :

Biological Significance: The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine.

other info2 :

Immunogen: Full-length protein expressed in 293T cell transfected with human SLC18A2 expression vector.

products categories :

Cell Biology

products description :

Mouse monoclonal SLC18A2 antibody

ncbi gi num :

71051965

ncbi acc num :

AAH30593.1

ncbi mol weight :

22,980 Da

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Cocaine Addiction Pathway (546258); Cocaine Addiction Pathway (546273); Dopamine Neurotransmitter Release Cycle Pathway (106523); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); Na+/Cl- Dependent Neurotransmitter Transporters Pathway (161070)

ncbi summary :

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]

uniprot summary :

SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family. Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 10q25. Cellular Component: synaptic vesicle; cell soma; synaptic vesicle membrane; membrane; integral to plasma membrane; plasma membrane; terminal button. Molecular Function: serotonin transmembrane transporter activity; enzyme binding; amine transmembrane transporter activity; heat shock protein binding; monoamine transmembrane transporter activity; drug binding. Biological Process: dopamine transport; amine transport; death; neurotransmitter secretion; response to amphetamine; monoamine transport; locomotory behavior; response to herbicide; sequestering of neurotransmitter; glucose homeostasis; endocytic recycling; response to cocaine; post-embryonic development; response to starvation; synaptic transmission; insulin secretion; response to zinc ion; serotonin transport; transmembrane transport; negative regulation of neurotransmitter transport; response to corticosterone stimulus; aging

size1 :

0.1 mL

price1 :

760 USD

more info or order :

MyBioSource product webpage