PSMA4 antibody | MyBioSource MBS833015 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PSMA4 antibody

catalog :

MBS833015

quantity :

0.1 mL

price :

515 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B8

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS833015

products type :

Antibody

products full name :

PSMA4 antibody

products short name :

PSMA4

products name syn :

Monoclonal PSMA4; Anti-PSMA4; Proteasome macropain subunit alpha type 4; Prosome Macropain Subunit Alpha Type 4; HC9; HsT17706; MGC111191; MGC12467; MGC24813; PSMA4; PSMA 4; PSMA-4

other names :

proteasome subunit alpha type-4 isoform 1; Proteasome subunit alpha type-4; proteasome subunit alpha type-4; proteasome (prosome, macropain) subunit, alpha type, 4; Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L

products gene name :

PSMA4

other gene names :

PSMA4; PSMA4; HC9; PSC9; HsT17706; HC9; PSC9

uniprot entry name :

PSA4_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

4B8

host :

Mouse

reactivity :

Human, Rat, Monkey, Mouse

sequence length :

261

purity :

PSMA4 antibody was purified by affinity chromatography.

form :

Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

concentration :

500 ug-1 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC), Western Blot (WB)

app notes :

IHC: 1:150. WB: 1:500-2000

other info1 :

Biological Significance: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure.

other info2 :

Immunogen: PSMA4 antibody was raised in mouse using a full length recombinant protein of human PSMA4 (NP_002780) produced in HEK293T cells, as the immunogen.

products categories :

Protein Modification & Stress Response

products description :

Mouse monoclonal PSMA4 antibody

ncbi gi num :

4506185

ncbi acc num :

NP_002780

ncbi gb acc num :

NM_002789.4

uniprot acc num :

P25789

ncbi mol weight :

21,365 Da

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); APC/C:Cdc20 Mediated Degradation Of Securin Pathway (105833); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105831); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (105835); APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway (1127549); AUF1 (hnRNP D0) Destabilizes MRNA Pathway (187212); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105829); Activation Of NF-kappaB In B Cells Pathway (576251); Adaptive Immune System Pathway (366160); Antigen Processing-Cross Presentation Pathway (477122)

ncbi summary :

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

PSMA4: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Belongs to the peptidase T1A family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.25.1; Proteasome complex; Protease. Chromosomal Location of Human Ortholog: 15q25.1. Cellular Component: proteasome complex; nucleoplasm; proteasome core complex; intracellular membrane-bound organelle; cytoplasm; plasma membrane; cytosol; nucleus. Molecular Function: threonine endopeptidase activity; protein binding. Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle

size1 :

0.1 mL

price1 :

515 USD

more info or order :

MyBioSource product webpage