Haptoglobin antibody | MyBioSource MBS832874 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Haptoglobin antibody

catalog :

MBS832874

quantity :

1 mg

price :

275 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS832874

products type :

Antibody

products full name :

Haptoglobin antibody

products short name :

[Haptoglobin]

products name syn :

[Polyclonal Haptoglobin; alpha polypeptide; MGC111141; HP; HPA1S; beta polypeptide; HPT; Hp2 alpha; Haptoglobin; HP2 ALPHA2]

other names :

[haptoglobin; Haptoglobin; haptoglobin; haptoglobin; Zonulin]

other gene names :

[HP; HP; BP; HPA1S; HP2ALPHA2]

uniprot entry name :

HPT_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Specific for Human Haptoglobin.

sequence length :

406

specificity :

Haptoglobin antibody was raised against Human Haptoglobin.

purity :

> 95% pure. Affinity purified using solid phase Human Haptoglobin

form :

Affinity purified liquid in 10 mM Sodium Phosphate, pH 7.2 with 150 mM NaCI and 0.05% NaN 3 .

concentration :

9.59 mg/ml

storage stability :

Store at 4°C.

tested application :

Suitable for use in ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), CL , FACS, IM, and IF.

app notes :

The optimal working dilution should be determined by the end user

other info1 :

Source Note: Goat serum was obtained from healthy animals of US origin and under the care of a registered veterinarian. Biological Significance: In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobulin assay is used to screen for and monitor intravascular hemolytic anemia.

other info2 :

Immunogen: Human Haptoglobin

products categories :

Nutrition & Metabolism; Purified Polyclonal Antibodies

products description :

Affinity purified Goat polyclonal Haptoglobin antibody

ncbi gi num :

386783

ncbi acc num :

AAA88080.1

ncbi mol weight :

38,452 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600); Vesicle-mediated Transport Pathway (1183600); Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

uniprot summary :

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity. Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; negative regulation of oxidoreductase activity; defense response to bacterium; acute-phase response; defense response. Disease: Anhaptoglobinemia

size1 :

1 mg

price1 :

275 USD

more info or order :

MyBioSource product webpage