catalog number :
MBS832831
products full name :
Vesicular Acetylcholine Transporter antibody
products short name :
Vesicular Acetylcholine Transporter
products name syn :
Polyclonal Vesicular Acetylcholine Transporter; Anti Vesicular Acetylcholine Transporter; VAChT
other names :
vesicular acetylcholine transporter; Vesicular acetylcholine transporter; vesicular acetylcholine transporter; solute carrier family 18 (vesicular acetylcholine transporter), member 3; Solute carrier family 18 member 3
other gene names :
SLC18A3; SLC18A3; VACHT; VACHT; VAChT
uniprot entry name :
VACHT_HUMAN
reactivity :
To be determined by the end user
form :
Supplied in lyophilized form. Dissolve the antiserum in 50 - 100 ul distilled water and dilute further in 0.1 M PBS with 1% BSA and 0.1% Na-azide
storage stability :
Store at 2-8 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC)
app notes :
IHC: 1:800 - 1:1200
other info1 :
Biological Significance: The Vesicular acetylcholine transporter (VAChT) is a neurotransmitter transporter which is responsible for loading acetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion.
other info2 :
Immunogen: Vesicular Acetylcholine Transporter antibody was raised in rabbit using synthetic peptide from the C-terminus of human VAChT conjugated to BSA as the immunogen.
products categories :
Hormones & Steroids
products description :
Rabbit polyclonal Vesicular Acetylcholine Transporter antibody
ncbi acc num :
NP_003046.2
ncbi gb acc num :
NM_003055.2
ncbi mol weight :
56,903 Da
ncbi pathways :
Acetylcholine Neurotransmitter Release Cycle Pathway (106525); Cholinergic Synapse Pathway (217716); Neuronal System Pathway (106513); Neurotransmitter Release Cycle Pathway (106518); Synaptic Vesicle Pathway (672457); Synaptic Vesicle Cycle Pathway (373900); Synaptic Vesicle Cycle Pathway (373890); Transmission Across Chemical Synapses Pathway (106516)
ncbi summary :
This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
uniprot summary :
SLC18A3: Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: membrane; integral to plasma membrane; plasma membrane. Molecular Function: acetylcholine transmembrane transporter activity. Biological Process: synaptic transmission; acetylcholine transport; neurotransmitter secretion