product summary
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company name :
MyBioSource
product type :
antibody
product name :
TIMELESS antibody
catalog :
MBS832534
quantity :
0.1 mg
price :
370 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog, cow, zebrafish
application :
western blot
more info or order :
image
image 1 :
TIMELESS antibody (MBS832534) used at 0.2-1 ug/ml to detect target protein.
product information
catalog number :
MBS832534
products type :
Antibody
products full name :
TIMELESS antibody
products short name :
[TIMELESS]
products name syn :
[Polyclonal TIMELESS; Anti-TIMELESS; Drosophila; timeless homolog]
other names :
[protein timeless homolog; Protein timeless homolog; protein timeless homolog; timeless circadian clock]
products gene name :
[TIMELESS]
other gene names :
[TIMELESS; TIMELESS; TIM; TIM1; hTIM; hTIM]
uniprot entry name :
TIM_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Cow, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish
sequence length :
1208
form :
Liquid in PBS with 0.09% Sodium Azide
concentration :
1 mg/ml
storage stability :
4°C short term, -20°C long term
tested application :
Western Blot (WB)
app notes :
WB: 2.5 ug/ml. TIMELESS Blocking Peptide is also available for use as a blocking control in assays to test for specificity of this TIMELESS antibody
image1 heading :
Western Blot (WB)
other info1 :
Biological Significance: The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
other info2 :
Immunogen: Synthetic peptide directed toward the N terminal regiob of human TIMELESS
products categories :
DNA & RNA
products description :
Rabbit polyclonal TIMELESS antibody
ncbi gi num :
222136585
ncbi acc num :
NP_003911
ncbi gb acc num :
NM_003920.3
uniprot acc num :
Q9UNS1
ncbi pathways :
Circadian Rhythm Pathway (137978)
ncbi summary :
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
uniprot summary :
TIMELESS: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules. Belongs to the timeless family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 12q13.3. Cellular Component: microtubule cytoskeleton; nuclear chromatin; nucleolus; nucleus. Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity. Biological Process: circadian rhythm; mitosis; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; regulation of cell proliferation; branching morphogenesis of a tube; cell division; response to abiotic stimulus; morphogenesis of an epithelium; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; detection of abiotic stimulus; lung development
size1 :
0.1 mg
price1 :
370 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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