CCL5 antibody | MyBioSource MBS832494 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CCL5 antibody

catalog :

MBS832494

quantity :

0.1 mg

price :

370 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis using CCL5 antibody. CCL5 antibody used at 1.25 ug/ml to detect target protein.

product information

catalog number :

MBS832494

products type :

Antibody

products full name :

CCL5 antibody

products short name :

[CCL5]

products name syn :

[Polyclonal CCL5 antibody, Anti-CCL5 antibody, CCL-5 antibody, CCL 5, CCL5, CCL-5, Chemokine (C-C motif) ligand 5 antibody, CCL 5 antibody]

other names :

[C-C motif chemokine 5; C-C motif chemokine 5; C-C motif chemokine 5; chemokine (C-C motif) ligand 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES]

products gene name :

[CCL5]

other gene names :

[Ccl5; Ccl5; SISd; Scya5; RANTES; TCP228; MuRantes; Scya5]

uniprot entry name :

CCL5_MOUSE

clonality :

Polyclonal

host :

Rabbit

reactivity :

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat.

sequence length :

form :

Liquid in PBS buffer with 0.09% NaN 3 , and 2% Sucrose.

concentration :

1 mg/ml

storage stability :

Store at 4°C for short term, -20°C for long term. Avoid repeat freeze-thaws.

tested application :

Suitable for use in Western Blot (WB).

app notes :

WB: 1.25 ug/ml

image1 heading :

Western Blot

other info1 :

Biological Significance: Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases. CCL5, together with Th cytokine mRNA expression, is temporally up-regulated during pneumococcal carriage. CCL5 is an essential factor for the induction and maintenance of protective pneumococcal immunity

other info2 :

Immunogen: Synthetic peptide directed towards the middle region of mouse CCL5.

products categories :

Cytokines & Growth Factors

products description :

Rabbit polyclonal CCL5 antibody

ncbi gi num :

164698428

ncbi acc num :

NP_038681

ncbi gb acc num :

NM_013653.3

uniprot acc num :

P30882

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chemokine Receptors Bind Chemokines Pathway (1168363); Chemokine Signaling Pathway (99271); Chemokine Signaling Pathway (672435); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (1168361); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Cytosolic DNA-sensing Pathway (125146)

uniprot summary :

CCL5: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. By mitogens. T-cell and macrophage specific. Belongs to the intercrine beta (chemokine CC) family. Protein type: Cell adhesion; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine. Cellular Component: extracellular space; cell; cytoplasm; extracellular region; intracellular. Molecular Function: heparin binding; protein homodimerization activity; protein self-association; cytokine activity; receptor signaling protein tyrosine kinase activator activity; phosphoinositide phospholipase C activity; protein kinase activity; CCR1 chemokine receptor binding; chemokine activity; chemokine receptor binding; chemokine receptor antagonist activity; phospholipase activator activity; chemoattractant activity; CCR5 chemokine receptor binding. Biological Process: exocytosis; positive regulation of cell adhesion; positive regulation of osteoclast differentiation; positive regulation of smooth muscle cell proliferation; response to toxin; positive regulation of smooth muscle cell migration; chemotaxis; positive regulation of cell-cell adhesion mediated by integrin; protein amino acid phosphorylation; pseudopodium formation; positive regulation of homotypic cell-cell adhesion; leukocyte adhesion; cell-cell signaling; positive chemotaxis; calcium ion transport; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; positive regulation of T cell proliferation; inflammatory response; lymphocyte chemotaxis; protein tetramerization; phospholipase D activation; neutrophil activation; negative regulation of G-protein coupled receptor protein signaling pathway; MAPKKK cascade; positive regulation of cellular biosynthetic process; cellular calcium ion homeostasis; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cellular protein complex assembly; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of viral genome replication; response to cytokine stimulus; eosinophil chemotaxis; positive regulation of fever; immune response; positive regulation of calcium ion transport; positive regulation of neuron differentiation; positive regulation of defense response to virus by host; regulation of insulin secretion; positive regulation of epithelial cell proliferation; positive regulation of phosphorylation; regulation of T cell activation; positive regulation of cell migration

size1 :

0.1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage