antibody

VEGFR1 antibody

MBS832207

0.1 mg

455 USD

monoclonal

rat

nonconjugated

7A6

flow cytometry, FACS

Antibody

VEGFR1 antibody

VEGFR1

Monoclonal VEGFR1; Anti-VEGFR1; FMS-like tyrosine kinase 1; VEGF-R1; VEGFR1; FLT-1; VEGFR-1; VEGFR 1; Vascular Endothelial Growth Factor Receptor 1; Tyrosine-protein kinase receptor FLT

vascular endothelial growth factor receptor 1 isoform 4; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor 1; fms-related tyrosine kinase 1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor

VEGFR1

FLT1; FLT1; FLT; FLT-1; VEGFR1; VEGFR-1; FLT; FRT; VEGFR1; VEGFR-1; FLT-1; FLT

VGFR1_HUMAN

Monoclonal

IgG2a

7A6

Rat

541

Mouse

VEGFR1 antibody was purified by affinity chromatography.

Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.

500 ug/ml

Store at 2-8 degree C. Do not freeze. Protect from light.

Flow Cytometry (FC/FACS)

FC: <= 1 ug/test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest

Biological Significance: This 7A6 monoclonal antibody recognizes human VEGFR1. It is directed against the extracellular domain and can recognize both membrane-bound and soluble forms of VEGFR1, with approximate molecular weights of 180 kDa and 90 kDa, respectively. Mice lacking expression of VEGFR1 have disorganized vasculature and die in utero, however angiogenesis does not require the tyrosine kinase activity of VEGFR1 as expression of a membrane-bound form lacking the tyrosine kinase domain allows normal development. Although fertile and viable, mice lacking the tyrosine kinase domain of VEGFR1 do have a defect in the migration of macrophages. The soluble form of VEGFR1 can be detected in the serum of normal patients, and elevated levels of soluble VEGFR1 in pregnant women is associated with preeclampsia. Several tumor cell lines have been reported to express membrane-bound VEGFR1, including malignancies of hematopoietic origin.

Cytokines & Growth Factors

Rat monoclonal VEGFR1 antibody

229892302

NP_001153503.1

NM_001160031.1

P17948

41,175 Da

Angiogenesis Pathway 198772!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Glypican 1 Network Pathway 138010!!HIF-1 Signaling Pathway 695200

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

0.1 mg

455 USD