CD19 antibody | MyBioSource MBS831357 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD19 antibody

catalog :

MBS831357

quantity :

0.1 mL

price :

270 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[2E2B6B10]

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical analysis of paraffin-embedded human normal lymph node, showing cytoplasmic localization using CD19 antibody with DAB staining.

image 2 :

Western Blot showing CD19 antibody used against CD19 recombinant protein.

product information

catalog number :

MBS831357

products type :

Antibody

products full name :

CD19 antibody

products short name :

[CD19]

products name syn :

[Monoclonal CD19; Anti-CD19; B-lymphocyte antigen CD19; CD 19; CD19; Cluster of Differentiation 19; CD-19]

other names :

[CD19, partial; CD19; B-lymphocyte antigen CD19; CD19 molecule; CD19]

products gene name :

[CD19]

other gene names :

[CD19; CD19; B4; CVID3]

uniprot entry name :

Q71UW0_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

[2E2B6B10]

host :

Mouse

reactivity :

Human

sequence length :

form :

Purified liquid in PBS with 0.03% sodium azide.

concentration :

1.0 mg/ml

storage stability :

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

ELISA: 1:10,000. IHC: 1:200-1:1000. WB: 1:500-1:2000

image1 heading :

Immunohistochemical staining

image2 heading :

Western Blot

other info1 :

Biological Significance: CD19 is a protein that in humans is encoded by the CD19 gene. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase.

other info2 :

Immunogen: CD19 antibody was raised in Mouse using a purified recombinant fragment of human CD19 expressed in E Coli as the immunogen.

products categories :

Immunology

products description :

Mouse monoclonal CD19 antibody

ncbi gi num :

4105281

ncbi acc num :

AAD02340.1

uniprot acc num :

Q71UW0

ncbi mol weight :

10,185 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Constitutive Signaling By Aberrant PI3K In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764)

ncbi summary :

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

uniprot summary :

CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: protein complex; integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: receptor signaling protein activity. Biological Process: epidermal growth factor receptor signaling pathway; regulation of immune response; B cell receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; innate immune response; cellular defense response; positive regulation of release of sequestered calcium ion into cytosol. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3

size1 :

0.1 mL

price1 :

270 USD

more info or order :

MyBioSource product webpage