catalog number :
MBS831342
products full name :
HAO1 antibody
products short name :
HAO1
products name syn :
Monoclonal HAO1; Anti-HAO1; Hydroxyacid Oxidase; Glycolate Oxidase 1; GOX; GOX1; HAOX1; HAO1; HAO 1; HAO-1
other names :
hydroxyacid oxidase 1; Hydroxyacid oxidase 1; hydroxyacid oxidase 1; hydroxyacid oxidase (glycolate oxidase) 1; Glycolate oxidase; GOX
products gene name :
HAO1
other gene names :
HAO1; HAO1; GOX; GOX1; HAOX1; GOX1; HAOX1; HAOX1; GOX
uniprot entry name :
HAOX1_HUMAN
purity :
HAO1 antibody was purified by affinity chromatography.
form :
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
concentration :
0.68mg/ml
storage stability :
Ships refrigerated. Upon receipt, store at -20 degree C.
tested application :
Immunofluorescence (IF), Western Blot (WB)
app notes :
IF: 1:100. WB: 1:500-2000. Flow: 1:50-1:100
other info1 :
Biological Significance: Subcellular location of HAO1 is the peroxisome. Specifically, HAO1 is expressed primarily in liver and pancreas and is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids.
other info2 :
Immunogen: Full length human recombinant protein of human HAO1 produced in HEK293T cell.
products categories :
Proteases, Inhibitors, & Enzymes
products description :
Mouse monoclonal HAO1 antibody
ncbi gb acc num :
NM_017545.2
ncbi mol weight :
40,924 Da
ncbi pathways :
Biosynthesis Of Antibiotics Pathway (1144997); Glyoxylate And Dicarboxylate Metabolism Pathway (83002); Glyoxylate And Dicarboxylate Metabolism Pathway (383); Glyoxylate Metabolism Pathway (160990); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Peroxisome Pathway (131226); Peroxisome Pathway (131126)
ncbi summary :
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
uniprot summary :
HAO1: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate. Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Oxidoreductase; EC 1.1.3.15. Chromosomal Location of Human Ortholog: 20p12. Cellular Component: peroxisomal matrix; peroxisome. Molecular Function: glycolate oxidase activity; FMN binding; glyoxylate oxidase activity; (S)-2-hydroxy-acid oxidase activity; receptor binding. Biological Process: glyoxylate metabolic process; response to oxidative stress; glycolate catabolic process; fatty acid alpha-oxidation