CD86 antibody | MyBioSource MBS831174 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD86 antibody

catalog :

MBS831174

quantity :

0.1 mL

price :

455 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B3

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS831174

products type :

Antibody

products full name :

CD86 antibody

products short name :

CD86

products name syn :

Monoclonal CD86; Anti-CD86; CD86 antigen; CD86; CD 86; Cluster of Differentiation 86; B72; T-lymphocyte activation antigen CD86; Cluster of differentiation 86; B 72; CTLA-4 counter-receptor B7.2; CD-86; B-lymphocyte activation antigen B7 2

other names :

CD86, partial; T-lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; CD86 molecule; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD_antigen: CD86

products gene name :

CD86

other gene names :

CD86; CD86; B70; B7-2; B7.2; LAB72; CD28LG2; CD28LG2

uniprot entry name :

CD86_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1B3

host :

Mouse

reactivity :

Human

sequence length :

323

form :

Liquid containing 0.03% sodium azide

concentration :

1.0 mg/ml

storage stability :

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: 1:10,000. WB: 1:200-1:1000

other info1 :

Biological Significance: CD86 is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

other info2 :

Immunogen: CD86 antibody was raised in Mouse using a purified recombinant fragment of human CD86 expressed in E Coli as the immunogen.

products categories :

Immunology

products description :

Mouse monoclonal CD86 antibody

ncbi gi num :

49456643

ncbi acc num :

CAG46642.1

uniprot acc num :

P42081

ncbi mol weight :

28,420 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); CD28 Co-stimulation Pathway (119553); CD28 Dependent PI3K/Akt Signaling Pathway (119554); CD28 Dependent Vav1 Pathway (119555); CTLA4 Inhibitory Signaling Pathway (119556)

ncbi summary :

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

uniprot summary :

CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 3q21. Cellular Component: cell surface; intracellular membrane-bound organelle; plasma membrane; integral to membrane; external side of plasma membrane. Molecular Function: protein binding; coreceptor activity; receptor activity; receptor binding. Biological Process: positive regulation of lymphotoxin A biosynthetic process; nerve growth factor receptor signaling pathway; viral reproduction; T cell activation; negative regulation of T cell anergy; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process; positive regulation of T-helper 2 cell differentiation; cell-cell signaling; T cell proliferation during immune response; positive regulation of cell proliferation; response to yeast; defense response to virus; aging; response to drug; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; B cell activation; T cell costimulation; toll-like receptor signaling pathway; innate immune response; immune response

size1 :

0.1 mL

price1 :

455 USD

more info or order :

MyBioSource product webpage