catalog number :
MBS831112
products full name :
14.3.3 gamma antibody
products short name :
14.3.3 gamma
products name syn :
Monoclonal 14.3.3 gamma; Anti-14.3.3 gamma; 14-3-3 gamma; 14/3/3 gamma; 14.3.3 gamma
other names :
14-3-3 protein gamma; 14-3-3 protein gamma; 14-3-3 protein gamma; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma; Protein kinase C inhibitor protein 1; KCIP-1
products gene name :
14.3.3 gamma
other gene names :
YWHAG; YWHAG; PPP1R170; 14-3-3GAMMA; KCIP-1
uniprot entry name :
1433G_HUMAN
reactivity :
To be determined by end-user
purity :
14-3-3 gamma antibody was affinity purified using a synthetic peptide
form :
Supplied lyophilized from PBS, pH 7.4, with 1% BSA and 0.05% NaN3. Reconstitute with 1ml of distilled water.
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at 20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC), Western Blot (WB)
app notes :
IHC: 35 ug/ml. WB: 15 ug/ml
other info1 :
Source Note: Supernatant. Biological Significance: The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. This plethora of interacting proteins allows 14-3-3 to play important roles in a wide range of vital regulatory processes, such as mitogenic signal transduction, apoptotic cell death, and cell cycle control. Levels of 14-3-3 gamma in the brain are significantly increased in Alzheimer's disease and Down syndrome.
other info2 :
Immunogen: 14-3-3 gamma antibody was raised in mouse using a synthetic peptide for the Cterminal of Human 14-3-3 gamma (QQDDDGGEGNN) as the immunogen
products categories :
Cell Biology
products description :
Human 14.3.3 gamma antibody
ncbi acc num :
NP_036611.2
ncbi gb acc num :
NM_012479.3
ncbi mol weight :
28,303 Da
ncbi pathways :
Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Anchoring Of The Basal Body To The Plasma Membrane Pathway 1127503!!Apoptosis Pathway 105648!!Assembly Of The Primary Cilium Pathway 1127502!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Cell Cycle Pathway 530733!!Cell Cycle Checkpoints Pathway 105739!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 198811
ncbi summary :
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]