antibody

CDCP1 antibody

MBS830522

0.1 mL

515 USD

monoclonal

mouse

nonconjugated

2C1

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS

Antibody

CDCP1 antibody

CDCP1

Monoclonal CDCP1; Anti-CDCP1; CD318; Cluster of differentiation 318; Trask; Transmembrane associated with src kinases; CDCP1; CDCP 1; CDCP-1

CUB domain-containing protein 1 isoform 1; CUB domain-containing protein 1; CUB domain-containing protein 1; CUB domain containing protein 1; Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD_antigen: CD318

CDCP1

CDCP1; CDCP1; CD318; TRASK; SIMA135; TRASK; SIMA135

CDCP1_HUMAN

Monoclonal

IgG1

2C1

Mouse

Human

836

CDCP1 antibody was purified by affinity chromatography.

Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

500 ug-1 mg/ml

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

FC: 1:100. IF: 1:100. IHC: 1:150. WB: 1:200-500

Biological Significance: CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein isfound to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability ofcarcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in acancer cell line.

Immunogen: CDCP1 antibody was raised in mouse using a full length recombinant protein of human CDCP1 (NP_073753) produced in HEK293T cells, as the immunogen.

Cancer

Mouse monoclonal CDCP1 antibody

30410805

NP_073753

NM_022842.3

Q9H5V8

37,818 Da

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

CDCP1: a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted. Protein type: Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: extracellular region; plasma membrane; integral to membrane

0.1 mL

515 USD