antibody

C1 inhibitor antibody

MBS830446

0.1 mg

285 USD

monoclonal

mouse

nonconjugated

[KT28]

ELISA, enzyme immunoassay

Antibody

C1 inhibitor antibody

[C1 inhibitor]

[Monoclonal C1 inhibitor; Anti-C1 inhibitor; C1-inhibitor; C inhibitor 1; C inhibitor-1; C1 esterase inhibitor; C1 inhibitor]

[C1 inhibitor; Plasma protease C1 inhibitor; plasma protease C1 inhibitor; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1]

[SERPING1; SERPING1; C1IN; C1NH; HAE1; HAE2; C1INH; C1IN; C1NH; C1 Inh; C1Inh]

IC1_HUMAN

Monoclonal

IgG1

[KT28]

Mouse

Human

500

C1 inhibitor antibody was purified by Protein A chromatography.

Liquid in PBS containing 0.09% sodium azide as a preservative

1 mg/ml

4°C short term; -20°C for long term. Avoid repeated freeze/thaw cycles.

ELISA (EIA)

ELISA: 1 ug/ml

Immunogen: Purified C1 inhibitor from human blood.: Biohazard Information: This product contains sodium azide which is hazardous

Proteases, Inhibitors, & Enzymes

C1 inhibitor is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation. C1-inhibitor is an acute-phase protein that circulates in blood at levels of around 0.25 g/L. The levels rise ~2-fold during inflammation. C1-inhibitor irreversibly binds to and inactivates C1r and C1s proteases in the C1 complex of classical pathway of complement.

1197499

CAA30314.1

P05155

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Intrinsic Pathway Of Fibrin Clot Formation (106059); Pertussis Pathway (218111); Pertussis Pathway (218099); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050)

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 11q12.1. Cellular Component: extracellular space; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding. Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging. Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I

0.1 mg

285 USD