catalog number :
MBS8304041
products full name :
Anti-FAM35A/B Antibody
products short name :
[FAM35A/B]
products name syn :
[FAM35A; Protein FAM35A; FAM35B; Protein FAM35B]
other names :
[shieldin complex subunit 2 isoform 1; Shieldin complex subunit 2; shieldin complex subunit 2; protein FAM35A; shieldin complex subunit 2; Protein FAM35A]
products gene name :
[FAM35A/B]
products gene name syn :
[FAM35A; FAM35B]
other gene names :
[SHLD2; SHLD2; RINN2; FAM35A; FAM35A1; bA163M19.1; FAM35AImportedManual assertion inferred from database entriesiHGNC:28773; RINN21 PublicationManual assertion based on opinion iniRef.5]
reactivity :
Human, Mouse, Rat
specificity :
Recognizes endogenous levels of FAM35A/B protein.
purity :
Purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
storage stability :
Shipping: Blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:1000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FAM35A/B. The exact sequence is propietary.
products description :
Rabbit polyclonal antibody to FAM35A/B
ncbi acc num :
NP_001317041.1
ncbi gb acc num :
NM_001330112.1
uniprot summary :
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).