antibody

Keratin K18 antibody

MBS830308

5 mL

265 USD

monoclonal

mouse

nonconjugated

Ks18.27

human, cow

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Keratin K18 antibody

Keratin K18

Monoclonal KRT18; Anti-KRT18; Keratin K-18; Keratin type I cytoskeletal 18; Keratin K18; Kerd; Keratin D; CYK18; Keratin 18; Cell proliferation inducing protein 46; Keratin K 18; Cell proliferation inducing gene 46 protein; K18; Cytokeratin 18; CK 18; Cytokeratin endo B

keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 18; keratin, type I cytoskeletal 18; keratin 18, type I; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18

KRT18; KRT18; K18; CYK18; CYK18; CK-18; K18

K1C18_HUMAN

Monoclonal

IgG1

Ks18.27

Mouse

Bovine

430

Supplied in liquid form, contains 0.09% NaN3

5ml

Store at 2-8 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Biological Significance: Keratin, type I cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18. Antibodies to CK8 can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

Immunogen: Keratin K18 antibody was raised in mouse using Cytoskeletal preparation from tumor cell line MCF-7 as the immunogen.

Cell Biology

Mouse monoclonal Keratin K18 antibody

40354195

NP_954657.1

NM_199187.1

P05783

48,058 Da

Caspase Cascade In Apoptosis Pathway (137974); EGFR1 Signaling Pathway (198782); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459); Pathogenic Escherichia Coli Infection Pathway (516)

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis. Protein type: Nucleolus; Cytoskeletal. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: perinuclear region of cytoplasm; keratin filament; cytoplasm; nucleolus; microtubule organizing center; intermediate filament. Molecular Function: protein binding; structural molecule activity. Biological Process: anatomical structure morphogenesis; tumor necrosis factor-mediated signaling pathway; viral reproduction; intermediate filament cytoskeleton organization and biogenesis; cell cycle; Golgi to plasma membrane CFTR protein transport; negative regulation of apoptosis. Disease: Cirrhosis, Familial

5 mL

265 USD