CORO1A antibody | MyBioSource MBS830281 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CORO1A antibody

catalog :

MBS830281

quantity :

0.1 mL

price :

585 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1A5

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS830281

products type :

Antibody

products full name :

CORO1A antibody

products short name :

CORO1A

products name syn :

Monoclonal CORO1A; Anti-CORO1A; Coronin actin binding protein 1A; TACO; HCORO1; Coronin 1; p57; Coronin like protein A; Tryptophan aspartate containing coat protein; CORO1A; COROA 1; COROA-1

other names :

coronin-1A; Coronin-1A; coronin-1A; coronin, actin binding protein, 1A; Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO

products gene name :

CORO1A

other gene names :

CORO1A; CORO1A; p57; IMD8; TACO; CLABP; HCORO1; CLIPINA; CORO1; Clipin-A; TACO

uniprot entry name :

COR1A_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1A5

host :

Mouse

reactivity :

Human

sequence length :

461

purity :

CORO1A antibody was purified by affinity chromatography.

form :

Liquid in PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

concentration :

0.8 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

app notes :

FC: 1:100. IF: 1:100. WB: 1:500-2000

other info1 :

Biological Significance: CORO1A is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation.

other info2 :

Immunogen: CORO1A antibody was raised in mouse using a full length recombinant protein of human CORO1A (NP_009005) produced in HEK293T cells, as the immunogen.

products categories :

Cell Biology

products description :

Mouse monoclonal CORO1A antibody

ncbi gi num :

5902134

ncbi acc num :

NP_009005

ncbi gb acc num :

NM_007074.3

uniprot acc num :

P31146

ncbi mol weight :

51,026 Da

ncbi pathways :

Phagosome Pathway (153910); Phagosome Pathway (153859); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

ncbi summary :

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

uniprot summary :

coronin 1A: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: phagocytic vesicle membrane; cortical actin cytoskeleton; protein complex; membrane; lamellipodium; axon; early endosome; cytoplasm; plasma membrane; immunological synapse; actin filament; phagocytic vesicle; intercellular junction; nucleus; phagocytic cup. Molecular Function: protein C-terminus binding; actin filament binding; protein binding; protein homodimerization activity; cytoskeletal protein binding; phosphoinositide 3-kinase binding. Biological Process: negative regulation of vesicle fusion; leukocyte chemotaxis; actin filament organization; cell-substrate adhesion; phagocytosis; regulation of release of sequestered calcium ion into cytosol; uropod organization and biogenesis; phagolysosome formation; regulation of cell shape; regulation of actin filament polymerization; positive chemotaxis; homeostasis of number of cells within a tissue; negative regulation of actin nucleation; calcium ion transport; innate immune response; positive regulation of T cell proliferation; T cell homeostasis; negative regulation of neuron apoptosis; actin cytoskeleton organization and biogenesis; cell motility; positive regulation of cell migration. Disease: Immunodeficiency 8

size1 :

0.1 mL

price1 :

585 USD

more info or order :

MyBioSource product webpage