catalog number :
MBS830146
products full name :
SYP antibody
products short name :
[SYP]
products name syn :
[Monoclonal Synaptophysin; Anti Synaptophysin; SYP; Synaptophysin]
other names :
[synaptophysin; Synaptophysin; synaptophysin; synaptophysin; BM89 antigen; Major synaptic vesicle protein p38]
products gene name :
[SYP]
other gene names :
[Syp; Syp; Syn; p38; AI848995; A230093K24Rik]
uniprot entry name :
SYPH_MOUSE
reactivity :
Bovine, Human, Mouse, Rat.
specificity :
Bovine Synaptophysin
form :
Hybridoma cell culture supernatant containing 0.09% Sodium Azide.
storage stability :
Ships ambient or refrigerated. Upon receipt store at 4°C or aliquot and freeze at -20°C. Avoid repeat freeze/thaw cycles.
tested application :
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Optimal conditions to be determined by end user.
other info1 :
Biological Significance: Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses.
other info2 :
Immunogen: Synaptophysin from presynaptic vesicles, prepared from bovine brain.
products categories :
Cancer
products description :
Mouse monoclonal SYP antibody
ncbi acc num :
NP_033331.2
ncbi gb acc num :
NM_009305.2
uniprot summary :
SYP: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family. Protein type: Vesicle; Membrane protein, integral; Membrane protein, multi-pass. Cellular Component: neuron projection; protein complex; synaptic vesicle membrane; integral to membrane; terminal button; excitatory synapse; intracellular organelle; integral to synaptic vesicle membrane; presynaptic membrane; synaptic vesicle; membrane; presynaptic active zone; synapse; cytoplasmic vesicle; cell junction. Molecular Function: identical protein binding; protein domain specific binding; protein binding; transporter activity; protein complex binding; cholesterol binding; syntaxin-1 binding; SH2 domain binding. Biological Process: regulation of long-term neuronal synaptic plasticity; synaptic transmission; transport; endocytosis; regulation of short-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity