Anti-CD282 Antibody | MyBioSource MBS8291685 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CD282 Antibody

catalog :

MBS8291685

quantity :

0.05 mL

price :

175 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of CD282 expression in THP1 (A), mouse lung (B), rat brain (C) whole cell lysates.

product information

catalog number :

MBS8291685

products type :

Antibody

products full name :

Anti-CD282 Antibody

products short name :

[CD282]

products name syn :

[TIL4; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282]

other names :

[toll-like receptor 2; Toll-like receptor 2; toll-like receptor 2; toll like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD_antigen: CD282]

products gene name :

[CD282]

products gene name syn :

[TLR2]

other gene names :

[TLR2; TLR2; TIL4; CD282; TIL4]

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

784

specificity :

Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

purity :

Purified by immunogen affinity chromatography

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 1/500 - 1/2000

image1 heading :

Western Blot (WB)

products description :

Rabbit polyclonal antibody to CD282

ncbi gi num :

974005295

ncbi acc num :

NP_001305716.1

ncbi gb acc num :

NM_001318787.1

uniprot acc num :

O60603

ncbi mol weight :

89,838 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (1269236); Adaptive Immune System Pathway (1269171); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Antigen Processing-Cross Presentation Pathway (1269195); Antimicrobial Peptides Pathway (1457777); Beta Defensins Pathway (1269267); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Class I MHC Mediated Antigen Processing Presentation Pathway (1269192)

ncbi summary :

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

uniprot summary :

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM ().

size1 :

0.05 mL

price1 :

175 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage