catalog number :
MBS8291530
products full name :
Anti-Syncytin-2 Antibody
products short name :
[Syncytin-2]
products name syn :
[ERVFRDE1; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD; Syncytin-2]
other names :
[syncytin-2 preproprotein; Syncytin-2; syncytin-2; endogenous retrovirus group FRD member 1, envelope; Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD; HERV-FRD_6p24.1 provirus ancestral Env polyprotein]
products gene name :
[ERVFRD-1]
other gene names :
[ERVFRD-1; ERVFRD-1; envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD; ERVFRDE1; SU; TM]
reactivity :
Human, Mouse, Rat
specificity :
Recognizes endogenous levels of Syncytin-2 protein.
purity :
Purified by immunogen affinity chromatography
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipping: Blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1/500 - 1/2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant full length protein of human Syncytin-2
products description :
Rabbit polyclonal antibody to Syncytin-2
ncbi acc num :
NP_997465.1
ncbi gb acc num :
NM_207582.2
ncbi summary :
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]
uniprot summary :
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).