antibody

Anti-NUP98 Antibody

MBS8291461

0.05 mL

175 USD

polyclonal

rabbit

nonconjugated

human, mouse

Antibody

Anti-NUP98 Antibody

[NUP98]

[ADAR2; Nuclear pore complex protein Nup98-Nup96]

[nuclear pore complex protein Nup98 isoform 3 proprotein; Nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98; nucleoporin 98; Nuclear pore complex protein Nup98Alternative name(s):98 kDa nucleoporin; Nucleoporin Nup98; Nup98]

[NUP98]

[NUP98; NUP98; ADIR2; NUP96; NUP196; ADAR2; Nup98; Nup96]

Polyclonal

Rabbit

Human, Mouse

937

Recognizes endogenous levels of NUP98 protein.

Purified by immunogen affinity chromatography

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Ships on blue ice. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

WB: 1/500 - 1/2000

Western Blot (WB)

Immunogen: Recombinant full length protein of human NUP98

Rabbit polyclonal antibody to NUP98

56549643

NP_005378.4

NM_005387.6

P52948

Antiviral Mechanism By IFN-stimulated Genes Pathway (1269316); Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Cellular Response To Heat Stress Pathway (1270421); Cellular Responses To Stress Pathway (1270414); Cytokine Signaling In Immune System Pathway (1269310); Disease Pathway (1268854); Export Of Viral Ribonucleoproteins From Nucleus Pathway (1269121); Gene Expression Pathway (1269649); Gene Silencing By RNA Pathway (1269719)

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).

0.05 mL

175 USD

0.1 mL

220

0.2 mL

295