Recombinant Human TIMP1 Protein | MyBioSource MBS8249878 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human TIMP1 Protein

catalog :

MBS8249878

quantity :

0.01 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8249878

products type :

Recombinant Protein

products full name :

Recombinant Human TIMP1 Protein

products short name :

[TIMP1]

products name syn :

[CLGI; TIMP; Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1]

other names :

[metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1; metalloproteinase inhibitor 1; TIMP metallopeptidase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1]

products gene name :

[TIMP1]

other gene names :

[TIMP1; TIMP1; EPA; EPO; HCI; CLGI; TIMP; TIMP-1; CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1]

uniprot entry name :

TIMP1_HUMAN

reactivity :

Human

sequence length :

207

sequence :

CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIAVDHHHH HH

purity :

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

form :

Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

storage stability :

Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

tested application :

ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

other info1 :

Source: Human cells. Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.

other info2 :

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

products description :

Recombinant Human TIMP1 Protein is produced by our Mammalian expression system and the target gene encoding Cys24-Ala207 is expressed with a 6His tag at the C-terminus.

ncbi gi num :

4507509

ncbi acc num :

NP_003245.1

ncbi gb acc num :

NM_003254.2

uniprot acc num :

P01033

ncbi mol weight :

23,171 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (1270258); Cytokine Signaling In Immune System Pathway (1269310); Degradation Of The Extracellular Matrix Pathway (1270257); Extracellular Matrix Organization Pathway (1270244); HIF-1 Signaling Pathway (695200); Hemostasis Pathway (1269340); IL-6 Signaling Pathway (198864); IL1 And Megakaryocytes In Obesity Pathway (1458186); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (1269170)

ncbi summary :

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

uniprot summary :

TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: Xp11.3-p11.23. Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix. Molecular Function: cytokine activity; metalloendopeptidase inhibitor activity; protease binding; protein binding. Biological Process: extracellular matrix disassembly; negative regulation of catalytic activity; negative regulation of membrane protein ectodomain proteolysis; platelet degranulation; positive regulation of cell proliferation; response to cytokine stimulus; response to hormone stimulus

size1 :

0.01 mg

price1 :

255 USD

size2 :

0.05 mg

price2 :

635

size3 :

0.5 mg

price3 :

2370

more info or order :

MyBioSource product webpage