protein

Recombinant Human SPINK1 Protein

MBS8249821

0.01 mg

205 USD

Recombinant Protein

Recombinant Human SPINK1 Protein

[SPINK1]

[PSTI; Pancreatic secretory trypsin inhibitor; Serine protease inhibitor Kazal-type 1; Tumor-associated trypsin inhibitor; TATI]

[serine protease inhibitor Kazal-type 1; Serine protease inhibitor Kazal-type 1; serine protease inhibitor Kazal-type 1; serine peptidase inhibitor, Kazal type 1; Pancreatic secretory trypsin inhibitor]

[SPINK1]

[SPINK1; SPINK1; TCP; PCTT; PSTI; TATI; Spink3; PSTI; TATI]

ISK1_HUMAN

Human

79

DSLGREAKCY NELNGCTKIY DPVCGTDGNT YPNECVLCFE NRKRQTSILI QKSGPCVDHH HHHH

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

Liquid in a 0.2 uM filtered solution of 20mM MES, 150mM NaCl, 2mM CaCl2, 1mM DTT, 0.05% Brij35, 10% Glycerol, pH 6.0.

Store at -20°C to -80°C for one year. Avoid repeated freeze-thaw cycles. Shipping: Ships with dry ice.

ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

Source: Human cells. Endotoxin: Less than 0.1 ng/mug (1 IEU/ug) as determined by LAL test.

Directions for Use: Always centrifuge tubes before opening. It is not recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant Human SPINK1 Protein is produced by our Mammalian expression system and the target gene encoding Asp24-Cys79 is expressed with a 6His tag at the C-terminus.

45505132

NP_003113.2

NM_003122.4

P00995

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]

SPINK1: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q32. Cellular Component: acrosome; extracellular space. Molecular Function: endopeptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity. Biological Process: regulation of acrosome reaction. Disease: Pancreatitis, Hereditary; Tropical Calcific Pancreatitis

0.01 mg

205 USD

0.05 mg

465

0.5 mg

2080