catalog number :
MBS8249727
products type :
Recombinant Protein
products full name :
Recombinant Human SCG2 Protein
products short name :
[SCG2]
products name syn :
[CHGC; Secretogranin-2; Chromogranin-C; Secretogranin II; SgII]
other names :
[secretogranin-2; Secretogranin-2; secretogranin-2; secretogranin II; Chromogranin-C; Secretogranin II; SgII]
products gene name :
[SCG2]
other gene names :
[SCG2; SCG2; SN; CHGC; EM66; SgII; CHGC; SgII; SN]
uniprot entry name :
SCG2_HUMAN
sequence :
SFQRNQLLQK EPDLRLENVQ KFPSPEMIRA LEYIENLRQQ AHKEESSPDY NPYQGVSVPL QQKENGDESH LPERDSLSEE DWMRIILEAL RQAENEPQSA PKENKPYALN SEKNFPMDMS DDYETQQWPE RKLKHMQFPP MYEENSRDNP FKRTNEIVEE QYTPQSLATL ESVFQELGKL TGPNNQKRER MDEEQKLYTD DEDDIYKANN IAYEDVVGGE DWNPVEEKIE SQTQEEVRDS KENIEKNEQI NDEMKRSGQL GIQEEGLRKE SKDQLSDDVS KVIAYLKRLV NAAGSGRLQN GQNGERATRL FEKPLDSQSI YQLIEISRNL QIPPEDLIEM LKTGEKPNGS VEPERELDLP VDLDDISEAD LDHPDLFQNR MLSKSGYPKT PGGAGTEALP DGLSVEDILN LLGMESAANQ KTSYFPNPYN QEKVLPRLPY GAGRSRSNQL PKAAWIPHVE NRQMAYENLN DKDQELGEYL ARMLVKYPEI INSNQVKRVP GQGSSEGDLQ EEEQIEQAIK EHLNQGSSQE TDKLAPVSKR FPVGPPKNDD TPNRQYWDED LLMKVLEYLN QEKAEKGREH IAKRAMENMV DHHHHHH
purity :
Greater than 95% as determined by reducing SDS-PAGE.
form :
Lyophilized from a 0.2 uM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
storage stability :
Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
tested application :
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
other info1 :
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
other info2 :
Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
products description :
Recombinant Human SCG2 Protein is produced by our mammalian expression system and the target gene encoding Ser29-Met617 is expressed with a 6His tag at the C-terminus.
ncbi acc num :
NP_003460.2
ncbi gb acc num :
NM_003469.4
ncbi summary :
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
uniprot summary :
SCG2: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. Belongs to the chromogranin/secretogranin protein family. Protein type: Apoptosis; Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q35-q36. Cellular Component: extracellular space. Molecular Function: chemoattractant activity; cytokine activity; protein binding. Biological Process: angiogenesis; endothelial cell migration; eosinophil chemotaxis; induction of positive chemotaxis; inflammatory response; MAPKKK cascade; negative regulation of endothelial cell proliferation; positive chemotaxis; positive regulation of endothelial cell proliferation; protein secretion