catalog number :
MBS8249657
products type :
Recombinant Protein
products full name :
Recombinant Human PRTN3 Protein
products short name :
[PRTN3]
products name syn :
[MBN; Myeloblastin; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen]
other names :
[myeloblastin; Myeloblastin; myeloblastin; proteinase 3; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen]
products gene name :
[PRTN3]
other gene names :
[PRTN3; PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA; MBN; PR-3; PR3; NP-4]
uniprot entry name :
PRTN3_HUMAN
sequence :
AEIVGGHEAQ PHSRPYMASL QMRGNPGSHF CGGTLIHPSF VLTAAHCLRD IPQRLVNVVL GAHNVRTQEP TQQHFSVAQV FLNNYDAENK LNDVLLIQLS SPANLSASVA TVQLPQQDQP VPHGTQCLAM GWGRVGAHDP PAQVLQELNV TVVTFFCRPH NICTFVPRRK AGICFGDSGG PLICDGIIQG IDSFVIWGCA TRLFPDFFTR VALYVDWIRS TLRRVDHHHH HH
purity :
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
form :
Liquid in a 0.2 uM filtered solution of 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.
storage stability :
Store it at -20°C to -80°C for one year.
tested application :
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
other info1 :
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
other info2 :
Directions for Use: Always centrifuge tubes before opening. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze -thaw cycles.
products description :
Recombinant Human PRTN3 Protein is produced by our Mammalian expression system and the target gene encoding Ala26-Arg249 is expressed with a 6His tag at the C-terminus.
ncbi acc num :
NP_002768.3
ncbi gb acc num :
NM_002777.3
ncbi pathways :
Antimicrobial Peptides Pathway (1457777); C-MYB Transcription Factor Network Pathway (138073); Common Pathway Of Fibrin Clot Formation (1269371); Cytokine Signaling In Immune System Pathway (1269310); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368); Hemostasis Pathway (1269340); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Neutrophil Degranulation Pathway (1457780); Signaling By Interleukins Pathway (1269318)
uniprot summary :
PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily. Protein type: Cell cycle regulation; EC 3.4.21.76; Protease. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: cytosol; extracellular matrix; extracellular space; plasma membrane. Molecular Function: enzyme binding; serine-type endopeptidase activity; serine-type peptidase activity. Biological Process: blood coagulation; negative regulation of phagocytosis; positive regulation of cell proliferation