product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human PDCD1 Protein
catalog :
MBS8249557
quantity :
0.01 mg
price :
200 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS8249557
products type :
Recombinant Protein
products full name :
Recombinant Human PDCD1 Protein
products short name :
[PDCD1]
products name syn :
[PD1; Programmed cell death protein 1; Protein PD-1; hPD-1; CD279]
other names :
[programmed cell death protein 1; Programmed cell death protein 1; programmed cell death protein 1; programmed cell death 1; CD_antigen: CD279]
products gene name :
[PDCD1]
other gene names :
[PDCD1; PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; PD1; Protein PD-1; hPD-1]
uniprot entry name :
PDCD1_HUMAN
host :
Human cells
reactivity :
Human
sequence length :
288
sequence :
LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV TERRAEVPTA HPSPSPRPAG QFQHHHHHH
purity :
Greater than 95% as determined by reducing SDS-PAGE.
form :
Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
storage stability :
Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
tested application :
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
other info1 :
Quality Control: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
other info2 :
Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
products description :
Recombinant Human PDCD1 Protein is produced by our mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a 6His tag at the C-terminus.
ncbi gi num :
167857792
ncbi acc num :
NP_005009.2
ncbi gb acc num :
NM_005018.2
uniprot acc num :
Q15116
ncbi pathways :
Adaptive Immune System Pathway (1269171); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (1269177); Immune System Pathway (1269170); PD-1 Signaling Pathway (1269182); T Cell Receptor Signaling Pathway (83080); T Cell Receptor Signaling Pathway (491); T-Cell Receptor And Co-stimulatory Signaling Pathway (1458223); T-Cell Antigen Receptor (TCR) Pathway During Staphylococcus Aureus Infection (1458275)
ncbi summary :
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
uniprot summary :
PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells. Protein type: Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: plasma membrane. Molecular Function: protein binding; signal transducer activity. Biological Process: humoral immune response; multicellular organismal development; T cell costimulation. Disease: Systemic Lupus Erythematosus
size1 :
0.01 mg
price1 :
200 USD
size2 :
0.05 mg
price2 :
435
size3 :
0.5 mg
price3 :
2670
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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