protein

Recombinant Human MAX Protein

MBS8249433

0.01 mg

205 USD

Recombinant Protein

Recombinant Human MAX Protein

[MAX]

[BHLHD4; Protein max; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X]

[protein max isoform g; Protein max; protein max; MYC associated factor X; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X]

[MAX]

[MAX; MAX; bHLHd4; BHLHD4; bHLHd4]

MAX_HUMAN

E Coli

Human

87

MSDNDDIEVE SDADKRAHHN ALERKRRDHI KDSFHSLRDS VPSLQGEKAS RAQILDKATE YIQYMRRKNH THQQDIDDLK RQNALLEQQV RALEKARSSA QLQTNYPSSD NSLYTNAKGS TISAFDGGSD SSSESEPEEP QSRKKLRMEA SLEHHHHHH

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

Lyophilized from a 0.2 muM filtered solution of 20mM Tris-HCl, 50mM Imidazole, 250mM NaCl, pH 8.5.

Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.

ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

Quality Control: Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Recombinant Human MAX Protein is produced by our E Coli expression system and the target gene encoding Met1-Ser151 is expressed with a 6His tag at the C-terminus.

402794193

NP_001257997.1

NM_001271068.1

P61244

B Cell Receptor Signaling Pathway (198909); C-MYC Pathway (169344); Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Cyclin A:Cdk2-associated Events At S Phase Entry Pathway (1269778); Cyclin E Associated Events During G1/S Transition Pathway (1269769); G1/S Transition Pathway (1269768); Integrated Breast Cancer Pathway (219801); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048)

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.

0.01 mg

205 USD

0.05 mg

465

0.5 mg

2080