Recombinant Human IRF5 Protein | MyBioSource MBS8249321 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human IRF5 Protein

catalog :

MBS8249321

quantity :

0.01 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8249321

products type :

Recombinant Protein

products full name :

Recombinant Human IRF5 Protein

products short name :

[IRF5]

products name syn :

[Interferon regulatory factor 5; IRF-5]

other names :

[interferon regulatory factor 5 isoform b; Interferon regulatory factor 5; interferon regulatory factor 5; interferon regulatory factor 5]

products gene name :

[IRF5]

other gene names :

[IRF5; IRF5; SLEB10; IRF-5]

uniprot entry name :

IRF5_HUMAN

host :

E. coli

reactivity :

Human

sequence length :

498

sequence :

MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQLE HHHHHH

purity :

Greater than 95% as determined by reducing SDS-PAGE.

form :

Liquid in a a 0.2 um filtered solution of 20mM Tris, 150mM Nacl, 30% Glycerol, 1mM DTT, pH 8.0.

storage stability :

Store it at -20°C to -80°C for one year. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

other info1 :

Quality Control: Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

other info2 :

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

products description :

Recombinant Human IRF5 Protein is produced by our E. coli expression system and the target gene encoding Met1-Gln498 is expressed with a 6His tag at the C-terminus.

ncbi gi num :

291190719

ncbi acc num :

NP_001092097.2

ncbi gb acc num :

NM_001098627.3

uniprot acc num :

Q13568

ncbi pathways :

Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (1269310); Direct P53 Effectors Pathway (137939); Immune System Pathway (1269170); Interferon Signaling Pathway (1269311); Interferon Alpha/beta Signaling Pathway (1269312); Interferon Gamma Signaling Pathway (1269314); Regulation Of Toll-like Receptor Signaling Pathway (920955); Senescence And Autophagy In Cancer Pathway (198780); Toll-like Receptor Signaling Pathway (198855)

ncbi summary :

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

uniprot summary :

IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q32. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: protein binding. Biological Process: positive regulation of apoptosis; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of transcription from RNA polymerase II promoter; response to muramyl dipeptide; response to peptidoglycan. Disease: Inflammatory Bowel Disease 14; Systemic Lupus Erythematosus, Susceptibility To, 10

size1 :

0.01 mg

price1 :

255 USD

size2 :

0.05 mg

price2 :

635

size3 :

0.5 mg

price3 :

2370

more info or order :

MyBioSource product webpage