protein

Recombinant Human IL22RA2 Protein

MBS8249274

0.01 mg

205 USD

Recombinant Protein

Recombinant Human IL22RA2 Protein

[IL22RA2]

[Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-bin]

[interleukin-22 receptor subunit alpha-2 isoform 1; Interleukin-22 receptor subunit alpha-2; interleukin-22 receptor subunit alpha-2; interleukin 22 receptor subunit alpha 2; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16]

[IL22RA2]

[IL22RA2; IL22RA2; CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; IL22BP]

I22R2_HUMAN

Human cells

Human

TQSTHESLKP QRVQFQSRNF HNILQWQPGR ALTGNSSVYF VQYKIYGQRQ WKNKEDCWGT QELSCDLTSE TSDIQEPYYG RVRAASAGSY SEWSMTPRFT PWWETKIDPP VMNITQVNGS LLVILHAPNL PYRYQKEKNV SIEDYYELLY RVFIINNSLE KEQKVYEGAH RAVEIEALTP HSSYCVVAEI YQPMLDRRSQ RSEERCVEIP VDHHHHHH

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.

ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

Quality Control: Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Recombinant Human IL22RA2 Protein is produced by our mammalian expression system and the target gene encoding Thr22-Pro231 is expressed with a 6His tag at the C-terminus.

16418459

NP_443194.1

NM_052962.2

Q969J5

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Immune System Pathway (1269170); Interleukin-19, 20, 22, 24 Pathway (1383036); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Signaling By Interleukins Pathway (1269318)

This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

IL22RA2: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6q23.3. Cellular Component: extracellular region; integral to membrane; plasma membrane. Molecular Function: interleukin-22 binding; interleukin-22 receptor activity. Biological Process: regulation of tyrosine phosphorylation of Stat3 protein

0.01 mg

205 USD

0.05 mg

465

0.5 mg

2080