protein

Recombinant Mouse IL1B Protein

MBS8249256

0.01 mg

255 USD

Recombinant Protein

Recombinant Mouse IL1B Protein

[IL1B]

[IL1F2; Interleukin-1 beta; IL-1 beta; Catabolin]

[interleukin-1 beta; Interleukin-1 beta; interleukin-1 beta; interleukin 1 beta]

[IL1B]

[Il1b; Il1b; Il-1b; IL-1beta; IL-1 beta]

IL1B_MOUSE

Mouse

269

VPIRQLHYRL RDEQQKSLVL SDPYELKALH LNGQNINQQV IFSMSFVQGE PSNDKIPVAL GLKGKNLYLS CVMKDGTPTL QLESVDPKQY PKKKMEKRFV FNKIEVKSKV EFESAEFPNW YISTSQAEHK PVFLGNNSGQ DIIDFTMESV SS

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

Lyophilized from a 0.2 uM filtered solution of 50mM Tris-HCl, 50mM NaCl, pH 8.0.

Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.

E, WB, SDS-PAGE ,MS

. Source: E.Coli . Quality Control: Endotoxin: Less than 0.1 ng/ ug (1 IEU/ug) as determined by LAL test.

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Recombinant Mouse IL1B Protein is produced by E. coli. It is a single non-glycosylated polypeptide chain containing 152 amino acids with a molecular mass of 17400 Daltons.

6680415

NP_032387.1

NM_008361.4

P10749

AGE-RAGE Signaling Pathway In Diabetic Complications (1320037); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); African Trypanosomiasis Pathway (194387); African Trypanosomiasis Pathway (194323); Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (1458482); Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Antifolate Resistance Pathway (1440575)

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]

IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family. Protein type: Cytokine. Cellular Component: extracellular region; extracellular space; secretory granule; vesicle. Molecular Function: cytokine activity; interleukin-1 receptor binding; protein domain specific binding. Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; cytokine and chemokine mediated signaling pathway; elevation of cytosolic calcium ion concentration; germ cell programmed cell death; hyaluronan biosynthetic process; inflammatory response; interleukin-1 beta production; leukocyte migration; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; memory; negative regulation of cell proliferation; negative regulation of glutamate secretion; negative regulation of insulin receptor signaling pathway; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of astrocyte differentiation; positive regulation of chemokine biosynthetic process; positive regulation of fever; positive regulation of glial cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of heterotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of immature T cell proliferation in the thymus; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of lipid catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of mitosis; positive regulation of neuron apoptosis; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; positive regulation of prostaglandin secretion; positive regulation of protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein kinase B signaling cascade; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of insulin secretion; regulation of nitric-oxide synthase activity; response to ATP; response to carbohydrate stimulus; response to lipopolysaccharide; sequestering of triacylglycerol; social behavior

0.01 mg

255 USD

0.05 mg

635

0.5 mg

2370