Recombinant Human HP Protein | MyBioSource MBS8249166 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human HP Protein

catalog :

MBS8249166

quantity :

0.01 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8249166

products type :

Recombinant Protein

products full name :

Recombinant Human HP Protein

products short name :

[HP]

products name syn :

[Haptoglobin; Zonulin]

other names :

[haptoglobin isoform 2 preproprotein; Haptoglobin; haptoglobin; haptoglobin; Zonulin]

products gene name :

[HP]

other gene names :

[HP; HP; BP; HPA1S; HP2ALPHA2]

uniprot entry name :

HPT_HUMAN

host :

E Coli

reactivity :

Human

sequence :

VDSGNDVTDI ADDGCPKPPE IAHGYVEHSV RYQCKNYYKL RTEGDGVYTL NDKKQWINKA VGDKLPECEA DDGCPKPPEI AHGYVEHSVR YQCKNYYKLR TEGDGVYTLN NEKQWINKAV GDKLPECEAV CGKPKNPANP VQRILGGHLD AKGSFPWQAK MVSHHNLTTG ATLINEQWLL TTAKNLFLNH SENATAKDIA PTLTLYVGKK QLVEIEKVVL HPNYSQVDIG LIKLKQKVSV NERVMPICLP SKDYAEVGRV GYVSGWGRNA NFKFTDHLKY VMLPVADQDQ CIRHYEGSTV PEKKTPKSPV GVQPILNEHT FCAGMSKYQE DTCYGDAGSA FAVHDLEEDT WYATGILSFD KSCAVAEYGV YVKVTSIQDW VQKTIAENVD HHHHHH

purity :

Greater than 95% as determined by reducing SDS-PAGE.

form :

Lyophilized from a 0.2 uM filtered solution of PBS, 1mM DTT, pH 7.4.

storage stability :

Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

tested application :

ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

other info1 :

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

other info2 :

Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

products description :

Recombinant Human HP Protein is produced by our E Coli expression system and the target gene encoding Cys145-Asn406 is expressed with a 6His tag at the N-terminus.

ncbi gi num :

186910296

ncbi acc num :

NP_001119574.1

ncbi gb acc num :

NM_001126102.2

uniprot acc num :

P00738

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Neutrophil Degranulation Pathway (1457780); Scavenging Of Heme From Plasma Pathway (1269898); Vesicle-mediated Transport Pathway (1269876); Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

uniprot summary :

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Endoplasmic reticulum; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular region; extracellular space. Molecular Function: hemoglobin binding; protein binding. Biological Process: defense response; negative regulation of oxidoreductase activity; receptor-mediated endocytosis; response to hydrogen peroxide. Disease: Anhaptoglobinemia

size1 :

0.01 mg

price1 :

255 USD

size2 :

0.05 mg

price2 :

635

size3 :

0.5 mg

price3 :

2370

more info or order :

MyBioSource product webpage