catalog number :
MBS8248926
products type :
Recombinant Protein
products full name :
Recombinant Human DEFB4A/DEFB4B Protein
products short name :
[DEFB4A/DEFB4B]
products name syn :
[DEFB102; DEFB2; DEFB4; Beta-defensin 4A; Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1; SAP1]
other names :
[beta-defensin 4B; Beta-defensin 4A; beta-defensin 4B; defensin beta 4B; Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1; SAP1]
products gene name :
[DEFB4A]
products gene name syn :
[DEFB4B]
other gene names :
[DEFB4B; DEFB4A; DEFB4P; DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1]
uniprot entry name :
DFB4A_HUMAN
sequence :
GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
purity :
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
form :
Lyophilized from a 0.2 uM filtered solution of 20mM PB, 130mM NaCl, pH 7.4
storage stability :
Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
tested application :
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
other info1 :
Quality Control: Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
other info2 :
Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
products description :
Recombinant Human DEFB4A/DEFB4B Protein is produced by our E Coli expression system and the target gene encoding Gly24-Pro64 is expressed with a 6His tag at the C-terminus.
ncbi acc num :
NP_001192195.1
ncbi gb acc num :
NM_001205266.1
ncbi pathways :
Antimicrobial Peptides Pathway (1457777); Beta Defensins Pathway (1269267); Defensins Pathway (1269265); Immune System Pathway (1269170); Innate Immune System Pathway (1269203)
ncbi summary :
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
uniprot summary :
defensin, beta 2: Has antibacterial activity (Potential). Belongs to the beta-defensin family. LAP/TAP subfamily. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular region; extracellular space; Golgi lumen. Molecular Function: CCR6 chemokine receptor binding; protein binding. Biological Process: chemotaxis; defense response to bacterium; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; G-protein coupled receptor protein signaling pathway; immune response; innate immune response