catalog number :
MBS8248835
products type :
Recombinant Protein
products full name :
Recombinant Human CRISP3 Protein
products short name :
[CRISP3]
products name syn :
[Cysteine-rich secretory protein 3; CRISP-3; Specific granule protein of 28 kDa; SGP28]
other names :
[cysteine-rich secretory protein 3 isoform 2; Cysteine-rich secretory protein 3; cysteine-rich secretory protein 3; cysteine rich secretory protein 3; Specific granule protein of 28 kDa; SGP28]
products gene name :
[CRISP3]
other gene names :
[CRISP3; CRISP3; Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3; CRISP-3; SGP28]
uniprot entry name :
CRIS3_HUMAN
sequence :
NEDKDPAFTA LLTTQTQVQR EIVNKHNELR RAVSPPARNM LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL YMSSASSSWS QAIQSWFDEY NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR LYVPYEQGAP CASCPDNCDD GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC SNSIYVDHHH HHH
purity :
Greater than 95% as determined by reducing SDS-PAGE.
form :
Lyophilized from a 0.2 uM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
storage stability :
Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
tested application :
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
other info1 :
Quality Control : Endotoxin :Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
other info2 :
Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
products description :
Recombinant Human CRISP3 Protein is produced by our mammalian expression system and the target gene encoding Asn21-Tyr245 is expressed with a 6His tag at the C-terminus.
ncbi acc num :
NP_001177915.1
ncbi gb acc num :
NM_001190986.2
ncbi pathways :
Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Neutrophil Degranulation Pathway (1457780)
ncbi summary :
This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
uniprot summary :
CRISP3: Belongs to the CRISP family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6p12.3. Cellular Component: extracellular region; extracellular space; specific granule