Recombinant Human ACVR2B Protein | MyBioSource MBS8248506 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human ACVR2B Protein

catalog :

MBS8248506

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8248506

products type :

Recombinant Protein

products full name :

Recombinant Human ACVR2B Protein

products short name :

[ACVR2B]

products name syn :

[Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB]

other names :

[activin receptor type-2B; Activin receptor type-2B; activin receptor type-2B; activin A receptor type 2B; Activin receptor type IIB; ACTR-IIB]

products gene name :

[ACVR2B]

other gene names :

[ACVR2B; ACVR2B; HTX4; ACTRIIB; ActR-IIB; ACTR-IIB]

uniprot entry name :

AVR2B_HUMAN

host :

Human cells

reactivity :

Human

sequence length :

512

sequence :

SGRGEAETRE CIYYNANWEL ERTNQSGLER CEGEQDKRLH CYASWRNSSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VYFCCCEGNF CNERFTHLPE AGGPEVTYEP PPTAPTVDDI EGRMDEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH

purity :

Greater than 95% as determined by reducing SDS-PAGE.

form :

Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

storage stability :

Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

tested application :

ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

other info1 :

Quality Control: Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

other info2 :

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

products description :

Recombinant Human ACVR2B Protein is produced by our mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, 6His tag at the C-terminus.

ncbi gi num :

116734708

ncbi acc num :

NP_001097.2

ncbi gb acc num :

NM_001106.3

uniprot acc num :

Q13705

ncbi pathways :

Activin Signaling Pathway (1084757); Activin Signaling Pathway (1108220); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Developmental Biology Pathway (1270302); Factors And Pathways Affecting Insulin-like Growth Factor (IGF1)-Akt Signaling (1458215); Mesodermal Commitment Pathway (1458216); Regulation Of Signaling By NODAL Pathway (1270344)

ncbi summary :

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

uniprot summary :

ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor. Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily. Chromosomal Location of Human Ortholog: 3p22. Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane; protein complex; receptor complex. Molecular Function: activin receptor activity, type II; growth factor binding; protein binding; protein serine/threonine kinase activity. Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; lymphangiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of transcription, DNA-dependent; signal transduction; transmembrane receptor protein serine/threonine kinase signaling pathway. Disease: Heterotaxy, Visceral, 4, Autosomal

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

265

size3 :

0.5 mg

price3 :

1675

more info or order :

MyBioSource product webpage