Anti-Glutathione Peroxidase Antibody | MyBioSource MBS8248036 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Glutathione Peroxidase Antibody

catalog :

MBS8248036

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

HRP

reactivity :

human, mouse, rat, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Glutathione Peroxidase expression in THP1 (A), mouse liver (B), rat liver (C) whole cell lysates.

product information

catalog number :

MBS8248036

products type :

Antibody

products full name :

Anti-Glutathione Peroxidase Antibody

products short name :

[Glutathione Peroxidase]

products name syn :

[Glutathione peroxidase 1; GPx-1; GSHPx-1; Cellular glutathione peroxidase]

other names :

[glutathione peroxidase 1 isoform 1; Glutathione peroxidase 1; glutathione peroxidase 1; glutathione peroxidase 1; Cellular glutathione peroxidase]

products gene name :

[GPX1]

other gene names :

[GPX1; GPX1; GPXD; GSHPX1; GPx-1; GSHPx-1]

uniprot entry name :

GPX1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Bovine

sequence length :

203

specificity :

Recognizes endogenous levels of Glutathione Peroxidase protein.

purity :

The antibody was purified by affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipping: Blue Ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 1/500 - 1/2000

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Glutathione Peroxidase. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to Glutathione Peroxidase

ncbi gi num :

41406084

ncbi acc num :

NP_000572.2

ncbi gb acc num :

NM_000581.3

uniprot acc num :

P07203

ncbi pathways :

Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (1270087); Arachidonic Acid Metabolism Pathway (366); Cellular Responses To Stress Pathway (1270414); Detoxification Of Reactive Oxygen Species Pathway (1270420); Direct P53 Effectors Pathway (137939); Folate Metabolism Pathway (198833)

ncbi summary :

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants and multiple pseudogenes of this gene have been identified. [provided by RefSeq, Jul 2016]

uniprot summary :

GPX1: Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Protein type: EC 1.11.1.9; Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - glutathione; Oxidoreductase. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion. Molecular Function: glutathione peroxidase activity; SH3 domain binding. Biological Process: cell redox homeostasis; glutathione metabolic process; heart contraction; hydrogen peroxide catabolic process; lipoxygenase pathway; negative regulation of caspase activity; purine nucleotide catabolic process; regulation of gene expression, epigenetic; regulation of mammary gland epithelial cell proliferation; response to hydrogen peroxide; response to reactive oxygen species; response to selenium ion; UV protection. Disease: Glutathione Peroxidase Deficiency

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage