protein

TGF beta 2 Blocking Peptide

MBS8247945

1 mg

160 USD

Blocking Peptide

TGF beta 2 Blocking Peptide

[TGF beta 2]

[Transforming growth factor beta-2; TGF-beta-2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Polyergin]

[transforming growth factor beta-2 isoform 1; Transforming growth factor beta-2; transforming growth factor beta-2; transforming growth factor beta 2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF]

[TGFB2]

[TGFB2; TGFB2; LDS4; G-TSF; TGF-beta2; TGF-beta-2; G-TSF; LAP]

TGFB2_HUMAN

Synthetic

Human, Mouse, Rat, Bovine, Chicken, Pig

442

>85%

Lyophilized powder

Shipping: Blue ice. Store at -20°C for one year.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

The peptide is used to block Anti-TGF beta 2 Antibody reactivity.

208022653

NP_001129071.1

NM_001135599.3

P61812

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); ATF-2 Transcription Factor Network Pathway (138006); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116)

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

TGFB2: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q41. Cellular Component: axon; cell soma; extracellular matrix; extracellular region; extracellular space. Molecular Function: beta-amyloid binding; cytokine activity; protein binding; protein heterodimerization activity; protein homodimerization activity; punt binding; receptor binding; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta receptor binding. Biological Process: activation of protein kinase activity; angiogenesis; cardiac muscle cell proliferation; cardioblast differentiation; catagen; cell cycle arrest; cell death; cell migration; cell morphogenesis; cell proliferation; cell-cell signaling; collagen fibril organization; dopamine biosynthetic process; embryonic development; embryonic gut development; epithelial to mesenchymal transition; eye development; generation of neurons; glial cell migration; hair follicle development; hair follicle morphogenesis; heart development; heart morphogenesis; hemopoiesis; intercellular junction assembly and maintenance; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of immune response; negative regulation of Ras protein signal transduction; neuron development; neutrophil chemotaxis; platelet degranulation; positive regulation of cardioblast differentiation; positive regulation of catagen; positive regulation of cell adhesion mediated by integrin; positive regulation of cell cycle; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of immune response; positive regulation of integrin biosynthetic process; positive regulation of neuron apoptosis; positive regulation of ossification; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein secretion; positive regulation of stress-activated MAPK cascade; protein amino acid phosphorylation; regulation of transforming growth factor-beta2 production; response to drug; response to hypoxia; response to progesterone stimulus; response to wounding; salivary gland morphogenesis; SMAD protein nuclear translocation; somatic stem cell division; transforming growth factor beta receptor signaling pathway; uterine wall breakdown; wound healing. Disease: Loeys-dietz Syndrome 4

1 mg

160 USD

5 mg

305