protein

AXL Blocking Peptide

MBS8247765

1 mg

160 USD

Blocking Peptide

AXL Blocking Peptide

[AXL]

[UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene]

[tyrosine-protein kinase receptor UFO isoform 2; Tyrosine-protein kinase receptor UFO; tyrosine-protein kinase receptor UFO; AXL receptor tyrosine kinase; AXL oncogene]

[AXL]

[AXL; AXL; ARK; UFO; JTK11; Tyro7; UFO]

UFO_HUMAN

Human, Mouse, Rat

885

>85%

Lyophilized powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

Source: Synthetic. Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

The peptide is used to block Anti-AXL Antibody reactivity.

21536468

NP_001690.2

NM_001699.5

P30530

97,377 Da

EGFR Tyrosine Kinase Inhibitor Resistance Pathway (1404798); EGFR Tyrosine Kinase Inhibitor Resistance Pathway (1402107); Signal Transduction Pathway (1269379); Signaling By VEGF Pathway (1269480); VEGFA-VEGFR2 Pathway (1269483)

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Axl family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: cell surface; extracellular space; integral to plasma membrane; plasma membrane. Molecular Function: phosphatidylserine binding; protein binding; protein-tyrosine kinase activity. Biological Process: cell maturation; entry of virus into host cell; negative regulation of interferon-gamma production; phagocytosis; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; signal transduction; vascular endothelial growth factor receptor signaling pathway

1 mg

160 USD

5 mg

305