catalog number :
MBS8247528
products full name :
Anti-Neuroglobin Antibody
products short name :
[Neuroglobin]
products name syn :
[Neuroglobin]
other names :
[neuroglobin; Neuroglobin; neuroglobin; neuroglobin]
products gene name :
[NGB]
other gene names :
[NGB; NGB]
uniprot entry name :
NGB_HUMAN
specificity :
Recognizes endogenous levels of Neuroglobin protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipping: Blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
app notes :
Western Blot: 1/500 - 1/2000. Immunofluorescence/Immunocytochemistry: 1/10 - 1/100
image1 heading :
Western Blot (WB)
image2 heading :
Immunofluorescence (IF)
other info1 :
Immunogen: Recombinant full length protein of human Neuroglobin
products description :
Rabbit polyclonal antibody to Neuroglobin
ncbi acc num :
NP_067080.1
ncbi gb acc num :
NM_021257.3
ncbi summary :
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
uniprot summary :
NGB: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. Belongs to the globin family. Chromosomal Location of Human Ortholog: 14q24.3. Molecular Function: oxygen transporter activity; protein binding