product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-Malcavernin Antibody
catalog :
MBS8245730
quantity :
0.05 mL
price :
175 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
image
image 1 :
Western blot analysis of Malcavernin expression in mouse brain (A), mouse testis (B) whole cell lysates.
image 2 :
Immunohistochemical analysis of Malcavernin staining in rat heart formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
product information
catalog number :
MBS8245730
products type :
Antibody
products full name :
Anti-Malcavernin Antibody
products short name :
[Malcavernin]
products name syn :
[C7orf22; Malcavernin; Cerebral cavernous malformations 2 protein]
other names :
[cerebral cavernous malformations 2 protein isoform 1; Cerebral cavernous malformations 2 protein; cerebral cavernous malformations 2 protein; CCM2 scaffolding protein; Malcavernin]
products gene name :
[CCM2]
other gene names :
[CCM2; CCM2; OSM; C7orf22; PP10187; C7orf22]
uniprot entry name :
CCM2_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
386
specificity :
Recognizes endogenous levels of Malcavernin protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1/500 - 1/2000; IHC: 1/50 - 1/200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant full length protein of human Malcavernin
products description :
Rabbit polyclonal antibody to Malcavernin
ncbi gi num :
71067341
ncbi acc num :
NP_001025006.1
ncbi gb acc num :
NM_001029835.2
uniprot acc num :
Q9BSQ5
ncbi mol weight :
42,073 Da
ncbi pathways :
Regulation Of P38-alpha And P38-beta Pathway (137964); P38 MAPK Signaling Pathway (137943)
ncbi summary :
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
uniprot summary :
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock ().
size1 :
0.05 mL
price1 :
175 USD
size2 :
0.1 mL
price2 :
220
size3 :
0.2 mL
price3 :
295
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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