Anti-EPHX1 Antibody | MyBioSource MBS8245670 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-EPHX1 Antibody

catalog :

MBS8245670

quantity :

0.05 mL

price :

175 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of EPHX1 expression in Jurkat (A), K562 (B), mouse liver (C) whole cell lysates.

image 2 :

Immunohistochemical analysis of EPHX1 staining in mouse liver formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

product information

catalog number :

MBS8245670

products type :

Antibody

products full name :

Anti-EPHX1 Antibody

products short name :

[EPHX1]

products name syn :

[EPHX; EPOX; Epoxide hydrolase 1; Epoxide hydratase; Microsomal epoxide hydrolase]

other names :

[epoxide hydrolase 1; Epoxide hydrolase 1; epoxide hydrolase 1; epoxide hydrolase 1; Epoxide hydratase; Microsomal epoxide hydrolase]

products gene name :

[EPHX1]

other gene names :

[EPHX1; EPHX1; MEH; EPHX; EPOX; HYL1; EPHX; EPOX]

uniprot entry name :

HYEP_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat

sequence length :

455

specificity :

Recognizes endogenous levels of EPHX1 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1/500 - 1/2000; IHC: 1/50 - 1/200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Rabbit. Immunogen: Recombinant full length protein of human EPHX1

products description :

Rabbit polyclonal antibody to EPHX1

ncbi gi num :

4503583

ncbi acc num :

NP_000111.1

ncbi gb acc num :

NM_000120.3

uniprot acc num :

P07099

ncbi mol weight :

52,949 Da

ncbi pathways :

Aflatoxin B1 Metabolism Pathway (198808); Benzo(a)pyrene Metabolism Pathway (198911); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Biological Oxidations Pathway (1270189); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Metabolism Pathway (1269956); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425)

ncbi summary :

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]

uniprot summary :

Ephx1: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls. Defects in EPHX1 are a cause of familial hypercholanemia (FHCA). FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Belongs to the peptidase S33 family. Protein type: EC 3.3.2.9; Membrane protein, integral; Xenobiotic Metabolism - metabolism by cytochrome P450; Hydrolase. Chromosomal Location of Human Ortholog: 1q42.1. Cellular Component: endoplasmic reticulum membrane; integral to membrane. Molecular Function: cis-stilbene-oxide hydrolase activity; epoxide hydrolase activity. Biological Process: aromatic compound catabolic process; response to organic cyclic substance; response to toxin; xenobiotic metabolic process. Disease: Hypercholanemia, Familial; Preeclampsia/eclampsia 1

size1 :

0.05 mL

price1 :

175 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage