product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-IRAK4 Antibody
catalog :
MBS8245430
quantity :
0.05 mL
price :
175 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of IRAK4 expression in MCF7 (A), Jurkat (B), Raji (C) whole cell lysates.
product information
catalog number :
MBS8245430
products type :
Antibody
products full name :
Anti-IRAK4 Antibody
products short name :
[IRAK4]
products name syn :
[Interleukin-1 receptor-associated kinase 4; IRAK-4; Renal carcinoma antigen NY-REN-64]
other names :
[interleukin-1 receptor-associated kinase 4 isoform a; Interleukin-1 receptor-associated kinase 4; interleukin-1 receptor-associated kinase 4; interleukin 1 receptor associated kinase 4; Renal carcinoma antigen NY-REN-64]
products gene name :
[IRAK4]
other gene names :
[IRAK4; IRAK4; IPD1; REN64; IRAK-4; NY-REN-64; IRAK-4]
uniprot entry name :
IRAK4_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
336
specificity :
Recognizes endogenous levels of IRAK4 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Ships on blue ice. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1/500 - 1/2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant full length protein of human IRAK4
products description :
Rabbit polyclonal antibody to IRAK4
ncbi gi num :
166795295
ncbi acc num :
NP_001107654.1
ncbi gb acc num :
NM_001114182.2
uniprot acc num :
Q9NWZ3
ncbi pathways :
AGE/RAGE Pathway (698754); Activated TLR4 Signalling Pathway (1269236); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine Signaling In Immune System Pathway (1269310); Disease Pathway (1268854); Diseases Associated With The TLR Signaling Cascade Pathway (1269157); Diseases Of Immune System Pathway (1269156); IL-1 Signaling Pathway (198908); IL1-mediated Signaling Events Pathway (137944)
ncbi summary :
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
uniprot summary :
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; IRAK family. Chromosomal Location of Human Ortholog: 12q12. Cellular Component: cytoplasm; cytosol; endosome membrane; extracellular space; nucleus; plasma membrane. Molecular Function: ATP binding; interleukin-1 receptor binding; magnesium ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity. Biological Process: cytokine and chemokine mediated signaling pathway; cytokine production; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; neutrophil mediated immunity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of smooth muscle cell proliferation; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway. Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
size1 :
0.05 mL
price1 :
175 USD
size2 :
0.1 mL
price2 :
220
size3 :
0.2 mL
price3 :
295
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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