protein

PAK2 Blocking Peptide

MBS8244520

1 mg

160 USD

Blocking Peptide

PAK2 Blocking Peptide

[PAK2]

[Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58]

[Serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 2; serine/threonine-protein kinase PAK 2; p21 protein (Cdc42/Rac)-activated kinase 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2]

[PAK2]

[PAK2; PAK2; PAK65; PAKgamma; PAK-2; p27; p34]

PAK2_HUMAN

Synthetic

Human, Mouse, Rat, Rabbit

524

>85%

Lyophilized Powder

Shipping: Blue Ice. Store at -20°C for one year.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4°C for overnight or at room temperature for 2 hours.

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

The peptide is used to block Anti-PAK2 Antibody reactivity.

143811432

Q13177.3

Q13177

Activation Of Rac Pathway (1270321); Adaptive Immune System Pathway (1269171); Apoptosis Pathway (1270262); Apoptotic Execution Phase Pathway (1270287); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (1270303); C-MYC Pathway (169344); C-type Lectin Receptors (CLRs) Pathway (1269303); CD209 (DC-SIGN) Signaling Pathway (1269309)

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

PAK2: a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; Kinase, protein; STE group; STE20 family; PAKA subfamily. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: cytoplasm; cytosol; nucleoplasm; perinuclear region of cytoplasm; plasma membrane. Molecular Function: ATP binding; identical protein binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activator activity; Rac GTPase binding. Biological Process: actin cytoskeleton organization and biogenesis; apoptosis; axon guidance; cell migration; cell structure disassembly during apoptosis; innate immune response; negative regulation of apoptosis; negative regulation of protein kinase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; programmed cell death; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of defense response to virus by virus; regulation of growth; regulation of MAPKKK cascade; regulation of mitotic cell cycle; Rho protein signal transduction; signal transduction; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated protein kinase signaling pathway; T cell costimulation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction

1 mg

160 USD

5 mg

305