GPR159 Blocking Peptide | MyBioSource MBS824377 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

GPR159 Blocking Peptide

catalog :

MBS824377

quantity :

1 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS824377

products type :

Blocking Peptide

products full name :

GPR159 Blocking Peptide

products short name :

[GPR159]

products name syn :

[CMKOR1; CXCR7; GPR159; RDC1; Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1]

other names :

[atypical chemokine receptor 3; Atypical chemokine receptor 3; atypical chemokine receptor 3; G protein-coupled receptor; chemokine orphan receptor 1; G-protein coupled receptor 159; C-X-C chemokine receptor type 7; chemokine (C-X-C motif) receptor 7; G-protein coupled receptor RDC1 homolog; atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1]

products gene name :

[CXCR7]

other gene names :

[ACKR3; ACKR3; RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159; CMKOR1; CXCR7; GPR159; RDC1; CXC-R7; CXCR-7; RDC-1]

uniprot entry name :

ACKR3_HUMAN

reactivity :

Human, Mouse, Rat, Dog

sequence length :

362

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipped at 4 degree C. Store at -20 degree C for one year.

tested application :

Blocking (BL)

app notes :

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

other info1 :

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

other info2 :

Source: Synthetic

products description :

The peptide is used to block Anti-GPR159 Antibody reactivity.

ncbi gi num :

31083344

ncbi acc num :

NP_064707.1

ncbi gb acc num :

NM_020311.2

uniprot acc num :

P25106

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Myometrial Relaxation And Contraction Pathways (198759); Peptide Ligand-binding Receptors Pathway (106358)

ncbi summary :

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

uniprot summary :

CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: recycling endosome; cell surface; perinuclear region of cytoplasm; early endosome; plasma membrane; integral to membrane; coated pit; endosome. Molecular Function: C-X-C chemokine binding; protein binding; coreceptor activity; scavenger receptor activity; C-X-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; viral reproduction; receptor internalization; angiogenesis; vasculogenesis; chemotaxis; cell adhesion

size1 :

1 mg

price1 :

160 USD

size2 :

5 mg

price2 :

305

more info or order :

MyBioSource product webpage