Laminin Receptor Blocking Peptide | MyBioSource MBS8243752 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Laminin Receptor Blocking Peptide

catalog :

MBS8243752

quantity :

1 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8243752

products type :

Blocking Peptide

products full name :

Laminin Receptor Blocking Peptide

products short name :

[Laminin Receptor]

products name syn :

[LAMBR; LAMR1; 40S ribosomal protein SA; 37 kDa laminin receptor precursor; 37LRP; 37/67 kDa laminin receptor; LRP/LR; 67 kDa laminin receptor; 67LR; Colon carcinoma laminin-binding protein; Laminin receptor 1; LamR; Laminin-binding protein precursor p40; LBP/p40; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4]

other names :

[40S ribosomal protein SA; 40S ribosomal protein SA; 40S ribosomal protein SA; ribosomal protein SA; 37 kDa laminin receptor precursor]

products gene name :

[RPSA]

other gene names :

[RPSA; RPSA; SA; LBP; LRP; p40; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4; 37LRP; LRP/LR; 67LR; LamR; LBP/p40]

uniprot entry name :

RSSA_HUMAN

host :

Synthetic

reactivity :

Human, Mouse, Rat, Bovine, Chicken, Pig, Sheep

sequence length :

295

purity :

>85%

form :

Lyophilized Powder

storage stability :

Shipped at 4°C. Store at -20°C for one year.

tested application :

Blocking (BL)

other info2 :

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. Directions for use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4°C for overnight or at room temperature for 2 hours.

products description :

The peptide is used to block Anti-Laminin Receptor Antibody (MBS8243752) reactivity.

ncbi gi num :

125969

ncbi acc num :

P08865.4

uniprot acc num :

P08865

ncbi pathways :

Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway (1268683); Alpha6-Beta4 Integrin Signaling Pathway (198807); Cap-dependent Translation Initiation Pathway (1268680); Cytoplasmic Ribosomal Proteins Pathway (198853); Disease Pathway (1268854); Eukaryotic Translation Elongation Pathway (1268690); Eukaryotic Translation Initiation Pathway (1268679); Eukaryotic Translation Termination Pathway (1268692); Formation Of A Pool Of Free 40S Subunits Pathway (1268681); Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway (1268682)

ncbi summary :

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

RPSA: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Belongs to the ribosomal protein S2P family. Protein type: Ribosomal. Chromosomal Location of Human Ortholog: 3p22.2. Cellular Component: cytoplasm; cytosol; membrane; nucleus; plasma membrane. Molecular Function: laminin binding; laminin receptor activity; protein binding; ribosome binding; structural constituent of ribosome; viral receptor activity. Biological Process: cell adhesion; cellular protein metabolic process; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); entry of virus into host cell; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit assembly and maintenance; rRNA export from nucleus; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription. Disease: Asplenia, Isolated Congenital

size1 :

1 mg

price1 :

160 USD

size2 :

5 mg

price2 :

305

more info or order :

MyBioSource product webpage