Glucose-6-Phosphate Dehydrogenase Microplate Assay Kit | MyBioSource MBS8243243 product information

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product summary

company name :

MyBioSource

product type :

other

product name :

Glucose-6-Phosphate Dehydrogenase Microplate Assay Kit

catalog :

MBS8243243

quantity :

100 Assays

price :

285 USD

product information

catalog number :

MBS8243243

products type :

Assay Kit

products full name :

Glucose-6-Phosphate Dehydrogenase Microplate Assay Kit

products short name :

[Glucose-6-Phosphate Dehydrogenase]

products name syn :

[EC 1.1.1.49; Glucose-6-phosphate dehydrogenase (NADP(+)); G6PD; G6PDH; Glucose-6-phosphate 1-dehydrogenase; Glucose-6-phosphate dehydrogenase; GPD]

other names :

[glucose-6-phosphate dehydrogenase, partial; Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase]

other gene names :

[G6PD; G6PD; G6PD1; G6PD]

uniprot entry name :

G6PD_HUMAN

reactivity :

General

sequence length :

101

storage stability :

Shipped and store at 4 degree C for 6 months.

tested application :

Functional Assay

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Tissue Extracts, Cell Lysate, Cell Culture And Other Biological Fluids Samples. Detection Range: 0.1 mmol/L-10 mmol/L

products description :

Background/Introduction: Glucose (C6H12O6) is a key diagnostic parameter for many metabolic disorders. Increased glucose levels have been associated with diabetes mellitus, hyperactivity of thyroid, pituitary and adrenal glands. Decreased levels are found in insulin secreting tumors, myxedema, hypopituitarism and hypoadrenalism. The assay is initiated with the enzymatic catalysis of glucose by glucose oxidase. The enzyme catalysed reaction products H2O2 react with the substrate, and can be measured at a colorimetric readout at 505 nm.

ncbi gi num :

299499

ncbi acc num :

AAB26169.1

ncbi mol weight :

62,468 Da

ncbi pathways :

Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Glutathione Metabolism Pathway (82973); Glutathione Metabolism Pathway (198824); Glutathione Metabolism Pathway (343); Metabolic Pathways (132956)

ncbi summary :

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

G6PD: glucose-6-phosphate dehydrogenase. A cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two splice variant isoforms have been described. The long isoform is found in lymphoblasts, granulocytes and sperm. Protein type: Other Amino Acids Metabolism - glutathione; EC 1.1.1.49; Carbohydrate Metabolism - pentose phosphate pathway; Oxidoreductase; Cell development/differentiation. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: centrosome; cytoplasm; cytosol; internal side of plasma membrane; intracellular membrane-bound organelle; membrane; microtubule organizing center; nucleus. Molecular Function: glucose binding; glucose-6-phosphate dehydrogenase activity; identical protein binding; NADP binding; protein binding; protein homodimerization activity. Biological Process: carbohydrate metabolic process; cholesterol biosynthetic process; erythrocyte maturation; gene expression; glucose 6-phosphate metabolic process; glucose metabolic process; glutathione metabolic process; lipid metabolic process; NADP metabolic process; NADPH regeneration; pentose biosynthetic process; pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; regulation of neuron apoptosis; response to ethanol; response to food; response to organic cyclic substance; ribose phosphate biosynthetic process; substantia nigra development; transcription initiation from RNA polymerase II promoter. Disease: Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency; Favism, Susceptibility To; Malaria, Susceptibility To

size1 :

100 Assays

price1 :

285 USD