Anti-SGK1 (pS78) Antibody | MyBioSource MBS8243157 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-SGK1 (pS78) Antibody

catalog :

MBS8243157

quantity :

0.03 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, cow, zebrafish

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of SGK1 (pS78) expression in HEK293T (A), A431 UV-treated (B) whole cell lysates.

product information

catalog number :

MBS8243157

products type :

Antibody

products full name :

Anti-SGK1 (pS78) Antibody

products short name :

[SGK1]

products name syn :

[SGK; Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1]

other names :

[Serine/threonine-protein kinase Sgk1; Serine/threonine-protein kinase Sgk1; serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid-regulated kinase 1]

products gene name :

[SGK1]

other gene names :

[SGK1; SGK1; SGK; SGK]

uniprot entry name :

SGK1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Bovine, Chicken, Monkey, Rabbit, Zebrafish

sequence length :

431

specificity :

Recognizes endogenous levels of SGK1 (pS78) protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

storage stability :

Shipping: Blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

Western Blot: (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SGK1 (pS78). The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to SGK1 (pS78)

ncbi gi num :

90185131

ncbi acc num :

O00141.2

uniprot acc num :

O00141

ncbi pathways :

Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Class I PI3K Signaling Events Pathway (138022); FSH Signaling Pathway (672455); FoxO Family Signaling Pathway (138036); FoxO Signaling Pathway (921162); Glucocorticoid Receptor Regulatory Network Pathway (138014); IL-6 Signaling Pathway (198864); Insulin Pathway (138026); Insulin Signaling Pathway (198845)

ncbi summary :

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

uniprot summary :

SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation. Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Motility/polarity/chemotaxis; Kinase, protein; AGC group; SGK family. Chromosomal Location of Human Ortholog: 6q23. Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane. Molecular Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; calcium channel regulator activity; chloride channel regulator activity; cofactor binding; potassium channel regulator activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity; tau protein binding. Biological Process: apoptosis; cellular sodium ion homeostasis; glucocorticoid mediated signaling; long-term memory; microtubule depolymerization; negative regulation of apoptosis; negative regulation of microtubule polymerization; neurite morphogenesis; peptidyl-serine phosphorylation; positive regulation of cell growth; positive regulation of dendrite morphogenesis; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of catalytic activity; regulation of cell cycle; regulation of cell growth; regulation of cell migration; regulation of cell proliferation; regulation of transcription factor activity; response to DNA damage stimulus; response to stress; sodium ion transport; transmembrane transport; visual learning

size1 :

0.03 mL

price1 :

165 USD

size2 :

0.1 mL

price2 :

245

size3 :

0.2 mL

price3 :

350

more info or order :

MyBioSource product webpage